An open label, multi-center clinical trial of topical 5% minoxidil solution for the treatment of male androgenetic alopecia (a phase IV study)
- Authors
- Park, H.-Y.; Lee, W.-S.; Park, J.; Kim, D.W.; Ahn, S.-Y.; Jung, Y.-J.; Ro, B.I.; Sim, W.Y.; Park, S.W.; Choi, G.S.; Kim, H.-O.; Huh, C.H.; Yoon, T.Y.; Kim, M.-B.; Kim, K.H.; Song, H.; Yun, S.J.
- Issue Date
- 2009
- Keywords
- 5% minoxidil; Androgenetic alopecia
- Citation
- Korean Journal of Dermatology, v.47, no.3, pp.295 - 302
- Indexed
- SCOPUS
KCI
- Journal Title
- Korean Journal of Dermatology
- Volume
- 47
- Number
- 3
- Start Page
- 295
- End Page
- 302
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/121912
- ISSN
- 0494-4739
- Abstract
- Background: Topical 5% minoxidil solution stimulates new hair growth and it helps stop the loss of hair on individuals with androgenetic alopecia (AGA). Objective: We wanted to assess the efficacy and safety of topical 5% minoxidil solution for treating Korean men with AGA. Methods: This was a 24-week, open label, clinical trial that was conducted at 14 university dermatologie centers nationwide throughout South Korea as a multicenter study of the Korean Hair Research Society. The eligible subjects for this study were 18- to 65 year-old men with androgenetic alopecia, as defined by the Norwood scale as type III vertex, IV and IVA. A total of 175 men (20-62 years old) with AGA applied topical 5% minoxidil solution twice daily. Efficacy was evaluated by 1) the total hair count per 1 cm2 and 2) the mean hair diameter and 3) the patient assessment and 4) the investigator assessment of the change in scalp coverage and the benefit of treatment. Results: At week 24 as compared with baseline, there was a statistically significant increase in the total hair counts and the mean hair diameter (p<.0001). Topical 5% minoxidil solution helped improve the investigator and patient assessments. The topical 5% minoxidil solution was well tolerated over a 24-week period. Conclusion: We believe that topical 5% minoxidil solution is a safe and effective drug for Korean men with AGA.
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