Antimicrobial Activities of the Anti-acne Compounds from Natural Sources
- Authors
- Nam, E.S.; Kim,; Narae,; Lim, Y.-H.; Park, S.W.
- Issue Date
- 2009
- Keywords
- Anti-acne; Antimicrobial activity; Propionibacterium acnes
- Citation
- Korean Journal of Microbiology and Biotechnology, v.37, no.1, pp.80 - 84
- Indexed
- SCOPUS
KCI
- Journal Title
- Korean Journal of Microbiology and Biotechnology
- Volume
- 37
- Number
- 1
- Start Page
- 80
- End Page
- 84
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/121913
- ISSN
- 1598-642X
- Abstract
- The in vitro antibacterial activities of anti-acne agents prepared from the extracts of natural sources were investigated against several bacteria including antibiotic-susceptible and -resistant Propionibacterium acnes. SD-1 and SD-2 were prepared with different formulations and they showed strong antibacterial activities. The anti-acne agents completely inhibited the growth of the tested strains at the concentration of 0.5%. There was no difference in antibacterial activity between antibiotic-susceptible and -resistant P. acnes. The inhibitory activities of two agents showed time-dependent manner. In S. aureus, time-kill curve demonstrated 2.8- and 3.4-log]o-unit killing after 8 h with SD-1 and SD-2, respectively. In P. acnes, time-killing curve demonstrated 5.1- and 6. l-logi0-unit killing after 24 h with SD-1 and SD-2, respectively. SD-2 showed stronger antimicrobial activity than SD-1. From these results, we expect that SD-1 and SD-2 have strong antibacterial activities and have advantages for treating acne.
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Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
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