Steroid Biosynthesis within the Frog Brain A Model of Neuroendocrine Regulation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Do Rego, Jean-Luc | - |
dc.contributor.author | Seong, Jae Young | - |
dc.contributor.author | Burel, Delphine | - |
dc.contributor.author | Van Luu-The | - |
dc.contributor.author | Larhammar, Dan | - |
dc.contributor.author | Tsutsui, Kazuyoshi | - |
dc.contributor.author | Pelletier, Georges | - |
dc.contributor.author | Tonon, Marie-Christine | - |
dc.contributor.author | Vaudry, Hubert | - |
dc.date.accessioned | 2021-09-09T01:04:44Z | - |
dc.date.available | 2021-09-09T01:04:44Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0077-8923 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/122116 | - |
dc.description.abstract | There is now clear evidence that the brain, similar to the adrenal gland, gonads, and placenta, is a steroidogenic organ. Notably in the frog brain, the presence of various steroidogenic enzymes has been detected by immunohistochemistry in specific populations of neurons and/or glial cells. These steroidogenic enzymes are biologically active, as shown by the ability of brain tissue explants to convert [H-3] pregnenolone into various radiolabeled steroids. The frog brain has also been extensively used as a model to study the mechanism of regulation of neurosteroidogenesis by neurotransmitters and neuropeptides. It has been demonstrated that the biosynthesis of neurosteroids is inhibited by gamma-aminobutyric acid (GABA), acting through GABA(A) receptors, and neuropeptide Y, acting through Y1 receptors, and is stimulated by the octadecaneuropepticle (ODN), acting through central-type benzodiazepine receptors, triakontatetraneuropeptide (TTN), acting through peripheral-type benzodiazepine receptors, and vasotocin, acting through V1a-like receptors. These data indicate that some of the neurophysiological effects of neurotransmitters and neuropeptides may be mediated through modulation of neurosteroid biosynthesis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject | DIAZEPAM-BINDING INHIBITOR | - |
dc.subject | CENTRAL-NERVOUS-SYSTEM | - |
dc.subject | 3-BETA-HYDROXYSTEROID DEHYDROGENASE DELTA(5)-DELTA(4)-ISOMERASE | - |
dc.subject | STIMULATES NEUROSTEROID BIOSYNTHESIS | - |
dc.subject | CHAIN CLEAVAGE ENZYME | - |
dc.subject | NEUROPEPTIDE-Y | - |
dc.subject | IMMUNOCYTOCHEMICAL LOCALIZATION | - |
dc.subject | BIOLOGICAL-ACTIVITY | - |
dc.subject | RAT-BRAIN | - |
dc.subject | GABA-A | - |
dc.title | Steroid Biosynthesis within the Frog Brain A Model of Neuroendocrine Regulation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Seong, Jae Young | - |
dc.identifier.doi | 10.1111/j.1749-6632.2008.03664.x | - |
dc.identifier.wosid | 000266493400007 | - |
dc.identifier.bibliographicCitation | TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY, v.1163, pp.83 - 92 | - |
dc.relation.isPartOf | TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY | - |
dc.citation.title | TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY | - |
dc.citation.volume | 1163 | - |
dc.citation.startPage | 83 | - |
dc.citation.endPage | 92 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | DIAZEPAM-BINDING INHIBITOR | - |
dc.subject.keywordPlus | CENTRAL-NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | 3-BETA-HYDROXYSTEROID DEHYDROGENASE DELTA(5)-DELTA(4)-ISOMERASE | - |
dc.subject.keywordPlus | STIMULATES NEUROSTEROID BIOSYNTHESIS | - |
dc.subject.keywordPlus | CHAIN CLEAVAGE ENZYME | - |
dc.subject.keywordPlus | NEUROPEPTIDE-Y | - |
dc.subject.keywordPlus | IMMUNOCYTOCHEMICAL LOCALIZATION | - |
dc.subject.keywordPlus | BIOLOGICAL-ACTIVITY | - |
dc.subject.keywordPlus | RAT-BRAIN | - |
dc.subject.keywordPlus | GABA-A | - |
dc.subject.keywordAuthor | neurosteroids | - |
dc.subject.keywordAuthor | brain | - |
dc.subject.keywordAuthor | neuropeptides | - |
dc.subject.keywordAuthor | neurotransmitters | - |
dc.subject.keywordAuthor | amphibians | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.