Steroid Biosynthesis within the Frog Brain A Model of Neuroendocrine Regulation
- Authors
- Do Rego, Jean-Luc; Seong, Jae Young; Burel, Delphine; Van Luu-The; Larhammar, Dan; Tsutsui, Kazuyoshi; Pelletier, Georges; Tonon, Marie-Christine; Vaudry, Hubert
- Issue Date
- 2009
- Publisher
- WILEY-BLACKWELL
- Keywords
- neurosteroids; brain; neuropeptides; neurotransmitters; amphibians
- Citation
- TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY, v.1163, pp.83 - 92
- Indexed
- SCIE
SCOPUS
- Journal Title
- TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY
- Volume
- 1163
- Start Page
- 83
- End Page
- 92
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/122116
- DOI
- 10.1111/j.1749-6632.2008.03664.x
- ISSN
- 0077-8923
- Abstract
- There is now clear evidence that the brain, similar to the adrenal gland, gonads, and placenta, is a steroidogenic organ. Notably in the frog brain, the presence of various steroidogenic enzymes has been detected by immunohistochemistry in specific populations of neurons and/or glial cells. These steroidogenic enzymes are biologically active, as shown by the ability of brain tissue explants to convert [H-3] pregnenolone into various radiolabeled steroids. The frog brain has also been extensively used as a model to study the mechanism of regulation of neurosteroidogenesis by neurotransmitters and neuropeptides. It has been demonstrated that the biosynthesis of neurosteroids is inhibited by gamma-aminobutyric acid (GABA), acting through GABA(A) receptors, and neuropeptide Y, acting through Y1 receptors, and is stimulated by the octadecaneuropepticle (ODN), acting through central-type benzodiazepine receptors, triakontatetraneuropeptide (TTN), acting through peripheral-type benzodiazepine receptors, and vasotocin, acting through V1a-like receptors. These data indicate that some of the neurophysiological effects of neurotransmitters and neuropeptides may be mediated through modulation of neurosteroid biosynthesis.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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