Risk Factors for Retinal Hemorrhage after Photodynamic Therapy in Age-Related Macular Degeneration
- Authors
- Oh, In Kyung; Huh, Kuhl; Oh, Jaeryung
- Issue Date
- 2009
- Publisher
- KARGER
- Keywords
- Photodynamic therapy; Retinal hemorrhage, risk factors; Macular degeneration, age-related
- Citation
- OPHTHALMOLOGICA, v.223, no.2, pp.78 - 84
- Indexed
- SCIE
SCOPUS
- Journal Title
- OPHTHALMOLOGICA
- Volume
- 223
- Number
- 2
- Start Page
- 78
- End Page
- 84
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/122166
- DOI
- 10.1159/000173715
- ISSN
- 0030-3755
- Abstract
- Background: Subretinal or intraretinal hemorrhage may occur after photodynamic therapy (PDT). However, risk factors for post-PDT hemorrhage have not yet been investigated. Methods: We reviewed the medical records of patients who had undergone PDT for subfoveal choroidal neovascularization secondary to age-related macular degeneration. Primary outcomes were the occurrences of hemorrhages at 2 and 12 weeks after PDT. To identify the risk factors of hemorrhages after treatment, ocular and systemic factors were investigated. The secondary outcome was visual acuity. Results: Ninety-two eyes from 92 patients were analyzed. New hemorrhages developed in 9 (9.8%) within 2 weeks and in 8 (8.3%) between 2 and 12 weeks after PDT. Hypertension [ odds ratio (OR) 356.9, 95% confidence interval (CI) 3.7-34,487.1], minimally classic lesion (OR 53.4, 95% CI 2-1,429) and advanced age (OR 1.2, 95% CI 1-1.5) were related to hemorrhagic events within 2 weeks after PDT. A tendency toward recurrent hemorrhage was noted after repeat treatments (p < 0.05). Forty-four percent of the patients with a hemorrhagic event within 2 weeks after PDT experienced decreased vision. Conclusion: Hypertension, minimally classic lesion, advanced age and a previous hemorrhagic event were associated with the development of hemorrhage within 2 weeks after PDT. Copyright (C) 2008 S. Karger AG, Basel
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