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Gold-layered calcium phosphate plasmonic resonants for localized photothermal treatment of human epithelial cancer
- Authors
- Kang, Jinyoung; Yang, Jaemoon; Lee, Jaewon; Oh, Seung Jae; Moon, Seyoung; Lee, Hong Jae; Lee, Sang Cheon; Son, Joo-Hiuk; Kim, Donghyun; Lee, Kwangyeol; Suh, Jin-Suck; Huh, Yong-Min; Haam, Seungjoo
- Issue Date
- 2009
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- JOURNAL OF MATERIALS CHEMISTRY, v.19, no.19, pp.2902 - 2905
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF MATERIALS CHEMISTRY
- Volume
- 19
- Number
- 19
- Start Page
- 2902
- End Page
- 2905
- ISSN
- 0959-9428
- Abstract
- We fabricated de novo biocompatible mineral plasmon resonants for localized and systemic treatment of cancer. Biodegradable calcium-phosphate gold nanocomposites were synthesized for inducing a superior surface plasmon resonance effect. The combination of therapeutic antibody, Erbitux (R) and NIR laser with nanocomposites demonstrated the potential for selective bimodal cancer treatment by combination of EGFR-induced signaling inhibition as a systemic treatment and localized photothermal effects caused by the NIR laser.
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