Immunostimulating and Anticancer Activities of Hot-water Extracts from Acanthopanax senticosus and Glycyrrhiza uralensis
DC Field | Value | Language |
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dc.contributor.author | Hwang, Jong-Hyun | - |
dc.contributor.author | Suh, Hyung-Joo | - |
dc.contributor.author | Yu, Kwang-Won | - |
dc.date.accessioned | 2021-09-09T01:54:52Z | - |
dc.date.available | 2021-09-09T01:54:52Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-12 | - |
dc.identifier.issn | 1226-7708 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/122257 | - |
dc.description.abstract | When 10 kinds of herbal medicines were fractionated into hexane, MeOH, cold-water, and hot-water extracts, hot-water extracts from Acanthopanax senticosus (AS), Glycyrrhiza uralensis (GU), Cichorium intybus (CI), and Polygonatum odoratum (PO) showed the potent intestinal immune system modulating activity (1.721-, 1.62-, 1.60-, and 1.53-fold of control at 100 mu g/mL, respectively). Especially, hot-water extracts from AS (215% compared with the control) and GU (187%) also had macrophages stimulating activity and mitogenic activity of splenocytes (7.1- and 6.5-fold) at 100 mu g/mL. In addition, the effects of hot-water extracts from herbal medicines on anticancer activities were studied in mice. Hot-water extracts from AS and GU enhanced cytotoxicity of natural killer cell against cancer cell, Yac-1 (37 and 34% cytotoxicity) at E/T ratio 100: 1, and colon 26-M3.1 cancer cell lines had significantly inhibited (82.1 and 75.2%) in experimental lung metastasis. These results Suggest that hot-water extracts from A. senticosus and G uralensis call be used as biological response modifiers to stimulate immune system and inhibit tumor. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST | - |
dc.subject | INNATE IMMUNITY | - |
dc.subject | ELEUTHEROCOCCUS-SENTICOSUS | - |
dc.subject | IN-VITRO | - |
dc.subject | POLYSACCHARIDES | - |
dc.subject | MICE | - |
dc.subject | MACROPHAGES | - |
dc.subject | ACTIVATION | - |
dc.subject | CANCER | - |
dc.subject | CELL | - |
dc.title | Immunostimulating and Anticancer Activities of Hot-water Extracts from Acanthopanax senticosus and Glycyrrhiza uralensis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung-Joo | - |
dc.identifier.scopusid | 2-s2.0-61349106655 | - |
dc.identifier.wosid | 000262223800010 | - |
dc.identifier.bibliographicCitation | FOOD SCIENCE AND BIOTECHNOLOGY, v.17, no.6, pp.1185 - 1190 | - |
dc.relation.isPartOf | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.citation.title | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.citation.volume | 17 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1185 | - |
dc.citation.endPage | 1190 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001300152 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | ELEUTHEROCOCCUS-SENTICOSUS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | POLYSACCHARIDES | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | CELL | - |
dc.subject.keywordAuthor | herbal medicine | - |
dc.subject.keywordAuthor | hot-water extract | - |
dc.subject.keywordAuthor | immunostimulating activity | - |
dc.subject.keywordAuthor | anticancer activity | - |
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