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Bioactive Cyclic Dipeptides from a Marine Sponge-Associated Bacterium, Psychrobacter sp.
- Authors
- Li, Huayue; Lee, Byung Cheol; Kim, Tae Sung; Bae, Kyung Sook; Hong, Jongki; Choi, Sang Ho; Bao, Baoquan; Jung, Jee Hyung
- Issue Date
- 12월-2008
- Publisher
- KOREAN SOC APPLIED PHARMACOLOGY
- Keywords
- Sponge-associated; Psychrobacter sp.; Cyclic dipeptide; D-proline; Vibrio vulnificus-induced cytotoxicity
- Citation
- BIOMOLECULES & THERAPEUTICS, v.16, no.4, pp.356 - 363
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BIOMOLECULES & THERAPEUTICS
- Volume
- 16
- Number
- 4
- Start Page
- 356
- End Page
- 363
- ISSN
- 1976-9148
- Abstract
- A bacterial strain with good antibacterial activities against Staphylococus aureus and Escherichia coli was isolated from a marine sponge Stelleta sp., and it was identified as a Psychrobacter sp. by comparative 16S rDNA sequence analysis. In our search for bioactive secondary metabolites from this psychrophillic and halotolerent bacterium, sixteen cyclic dipeptides (1-16) were isolated and their structures were identified on the basis of NMR analysis. In the test of the compounds for the protective effect against Vibrio vulnificus-induced cytotoxicity in human intestinal epithelial cells, cyclo-(L-Pro-L-Phe) (5) exhibited significant protective effect. Compounds 2, 6, and 11, which contain D-amino acid, were first isolated from bacteria.
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