National Survey for Drug-Resistant Variants in Newly Diagnosed Antiretroviral Drug-Naive Patients With HIV/AIDS in South Korea: 1999-2005
- Authors
- Choi, Ju-yeon; Kim, Eun-Jin; Park, Yong Keun; Lee, Doo-Shil; Kim, Sung Soon
- Issue Date
- 1-11월-2008
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- antiretroviral drug resistance; drug-naive; HIV-1 genotyping; South Koreans
- Citation
- JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, v.49, no.3, pp.237 - 242
- Indexed
- SCIE
SCOPUS
- Journal Title
- JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
- Volume
- 49
- Number
- 3
- Start Page
- 237
- End Page
- 242
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/122421
- DOI
- 10.1097/QAI.0b013e318188a919
- ISSN
- 1525-4135
- Abstract
- We investigated the prevalence of drug-resistant variants and assessed their severity against antiretroviral drugs among patients in South Korea. Three hundred antiretroviral drug-naive patients were collected and drug-resistant variants were analyzed using the Stanford database with sequences and mutation data of the HIV-1 genes for protease (codons 1-99) and reverse transcriptase (codons 1-250). Of this group, 199 isolates (66.3%) showed at least 1 or more sites related to drug resistance. However, the average prevalence of drug resistance for patients newly diagnosed with HIV-1 but still treatment-naive between 1999 and 2005 was very low (4.3%, by "SIR" interpretation) compared with other countries. Most of the newly infected patients carried HIV subtype B (96%, n = 288) based on phylogenetic analysis of the conserved pol region. In summary, there has been no significant increase in the prevalence of drug resistance among antiretroviral drug-naive patients infected with HIV-1 for the last 7 years in South Korea. This study is quite significant regarding its larger scale of prevalence study for drug-resistant variants comparing to other drug-resistant studies using small scale of populations in South Korea. It is also important to provide suitable guidelines of genotyping assays for Korean drug-naive patients.
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