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Inhibition of Diacylglycerol Acyltransferase by Phenylpyropenes Produced by Penicillium griseofulvum F1959
- Authors
- Lee, Seung Woong; Rho, Mun-Chual; Choi, Jung-Ho; Kim, Koanhoi; Choi, Yong Seok; Lee, Hyun Sun; Kim, Young Kook
- Issue Date
- 11월-2008
- Publisher
- KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
- Keywords
- Penicillium griseofulvum F1959; diacylglycerol acyltransferase (DGAT); phenylpyropene; triglyceride; hepG2 cell
- Citation
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.18, no.11, pp.1785 - 1788
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
- Volume
- 18
- Number
- 11
- Start Page
- 1785
- End Page
- 1788
- ISSN
- 1017-7825
- Abstract
- Phenylpyropenes A, B, and C, isolated from Penicillium griseofulvum F1959, inhibited DGAT in rat liver microsomes with IC50 values of 78.7 +/- 1.6, 21.7 +/- 0.2, and 11.04 +/- 0.2 mu M, respectively. In addition, a kinetic analysis using a Lineweaver-Burk plot revealed that phenylpyropene C was a noncompetitive inhibitor of DGAT. The apparent Michaelis constant (K-m) value and inhibition constant (K-i) value were calculated to be 8 mu M and 10.4 mu M, respectively. Moreover, phenylpyropene C inhibited triglyceride formation in HepG2 cells.
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