Hippocampal NMDA receptors are necessary for auditory trace fear conditioning measured with conditioned hypoalgesia in rats
DC Field | Value | Language |
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dc.contributor.author | Seo, Dong-Oh | - |
dc.contributor.author | Pang, Min-Hee | - |
dc.contributor.author | Shin, Maeng-Sik | - |
dc.contributor.author | Kim, Hyun-Taek | - |
dc.contributor.author | Choi, June-Seek | - |
dc.date.accessioned | 2021-09-09T03:39:15Z | - |
dc.date.available | 2021-09-09T03:39:15Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-10-10 | - |
dc.identifier.issn | 0166-4328 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/122566 | - |
dc.description.abstract | We tested whether N-methyl-D-aspartate (NMDA) receptors in the dorsal hippocampus (DH) are critical for the acquisition of trace fear conditioning using conditioned hypoalgesia (CHA), decrease in pain reactivity, as the conditioned response (CR) instead of commonly used freezing. Infusions of the NMDA receptor antagonist, DL-2-amino-5-phosphonovaleric acid (APV) into DH prior to conditioning resulted in impaired CHA, measured with the radiant heat tail flick test, only in the trace-conditioning group when they were tested during the trace interval. The same infusion had no effect on CHA in the delay-conditioned animals. The results support that NMDA receptors in DH are critically involved in associating the CS with the US across a temporal gap. in addition, temporal specificity of the CR was revealed as CHA was induced only in the temporal vicinity of the US used for the training. (C) 2008 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | TAIL-FLICK TEST | - |
dc.subject | DORSAL HIPPOCAMPUS | - |
dc.subject | BASOLATERAL AMYGDALA | - |
dc.subject | POTENTIATED STARTLE | - |
dc.subject | PERIAQUEDUCTAL GRAY | - |
dc.subject | OPIOID RECEPTORS | - |
dc.subject | DENTATE GYRUS | - |
dc.subject | LESIONS | - |
dc.subject | EXPRESSION | - |
dc.subject | PAIN | - |
dc.title | Hippocampal NMDA receptors are necessary for auditory trace fear conditioning measured with conditioned hypoalgesia in rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyun-Taek | - |
dc.contributor.affiliatedAuthor | Choi, June-Seek | - |
dc.identifier.doi | 10.1016/j.bbr.2008.04.011 | - |
dc.identifier.scopusid | 2-s2.0-46249130784 | - |
dc.identifier.wosid | 000258170200015 | - |
dc.identifier.bibliographicCitation | BEHAVIOURAL BRAIN RESEARCH, v.192, no.2, pp.264 - 268 | - |
dc.relation.isPartOf | BEHAVIOURAL BRAIN RESEARCH | - |
dc.citation.title | BEHAVIOURAL BRAIN RESEARCH | - |
dc.citation.volume | 192 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 264 | - |
dc.citation.endPage | 268 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Behavioral Sciences | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Behavioral Sciences | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | TAIL-FLICK TEST | - |
dc.subject.keywordPlus | DORSAL HIPPOCAMPUS | - |
dc.subject.keywordPlus | BASOLATERAL AMYGDALA | - |
dc.subject.keywordPlus | POTENTIATED STARTLE | - |
dc.subject.keywordPlus | PERIAQUEDUCTAL GRAY | - |
dc.subject.keywordPlus | OPIOID RECEPTORS | - |
dc.subject.keywordPlus | DENTATE GYRUS | - |
dc.subject.keywordPlus | LESIONS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PAIN | - |
dc.subject.keywordAuthor | trace conditioning | - |
dc.subject.keywordAuthor | conditioned hypoalgesia | - |
dc.subject.keywordAuthor | NMDA | - |
dc.subject.keywordAuthor | hippocampus | - |
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