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Hippocampal NMDA receptors are necessary for auditory trace fear conditioning measured with conditioned hypoalgesia in rats

Authors
Seo, Dong-OhPang, Min-HeeShin, Maeng-SikKim, Hyun-TaekChoi, June-Seek
Issue Date
10-10월-2008
Publisher
ELSEVIER SCIENCE BV
Keywords
trace conditioning; conditioned hypoalgesia; NMDA; hippocampus
Citation
BEHAVIOURAL BRAIN RESEARCH, v.192, no.2, pp.264 - 268
Indexed
SCIE
SCOPUS
Journal Title
BEHAVIOURAL BRAIN RESEARCH
Volume
192
Number
2
Start Page
264
End Page
268
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/122566
DOI
10.1016/j.bbr.2008.04.011
ISSN
0166-4328
Abstract
We tested whether N-methyl-D-aspartate (NMDA) receptors in the dorsal hippocampus (DH) are critical for the acquisition of trace fear conditioning using conditioned hypoalgesia (CHA), decrease in pain reactivity, as the conditioned response (CR) instead of commonly used freezing. Infusions of the NMDA receptor antagonist, DL-2-amino-5-phosphonovaleric acid (APV) into DH prior to conditioning resulted in impaired CHA, measured with the radiant heat tail flick test, only in the trace-conditioning group when they were tested during the trace interval. The same infusion had no effect on CHA in the delay-conditioned animals. The results support that NMDA receptors in DH are critically involved in associating the CS with the US across a temporal gap. in addition, temporal specificity of the CR was revealed as CHA was induced only in the temporal vicinity of the US used for the training. (C) 2008 Elsevier B.V. All rights reserved.
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