Innate immune stimulation of exo-polymers prepared from Cordyceps sinensis by submerged culture
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, Taek Joon | - |
dc.contributor.author | Yu, Kwang-Won | - |
dc.contributor.author | Shin, Kwang-Soon | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.date.accessioned | 2021-09-09T04:02:04Z | - |
dc.date.available | 2021-09-09T04:02:04Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-10 | - |
dc.identifier.issn | 0175-7598 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/122648 | - |
dc.description.abstract | After we prepared exo-polymers (EPS) from Cordyceps sinensis by submerged culture, prophylactic intravenous administration (i.v.) of EPS significantly inhibited metastasis in experimental lung metastasis of colon 26-M3.1 carcinoma. Cytotoxicity against Yac-1 tumor cells of natural killer (NK) cell, which was prepared by i.v. of EPS (100 mu g/mouse), significantly augmented 2 days after EPS treatment. When NK cells were depleted by rabbit anti-asialo GM1 serum, even the EPS group totally abolished the inhibitory effect on lung metastasis of colon 26-M3.1 cells. EPS can stimulate innate immune system to inhibit tumor metastasis, and its anti-tumor metastasis is associated with macrophage and NK cell activation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | BLOOD MONONUCLEAR-CELLS | - |
dc.subject | CANCER | - |
dc.subject | IMMUNOTHERAPY | - |
dc.subject | ACTIVATION | - |
dc.subject | MICE | - |
dc.subject | MYCELIA | - |
dc.subject | POLYSACCHARIDES | - |
dc.subject | INTERLEUKIN-12 | - |
dc.subject | MACROPHAGES | - |
dc.subject | COMBINATION | - |
dc.title | Innate immune stimulation of exo-polymers prepared from Cordyceps sinensis by submerged culture | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.1007/s00253-008-1607-y | - |
dc.identifier.scopusid | 2-s2.0-53249105353 | - |
dc.identifier.wosid | 000259670500015 | - |
dc.identifier.bibliographicCitation | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, v.80, no.6, pp.1087 - 1093 | - |
dc.relation.isPartOf | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | - |
dc.citation.title | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | - |
dc.citation.volume | 80 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1087 | - |
dc.citation.endPage | 1093 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.subject.keywordPlus | BLOOD MONONUCLEAR-CELLS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | MYCELIA | - |
dc.subject.keywordPlus | POLYSACCHARIDES | - |
dc.subject.keywordPlus | INTERLEUKIN-12 | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | COMBINATION | - |
dc.subject.keywordAuthor | Cordyceps sinensis | - |
dc.subject.keywordAuthor | innate immunity | - |
dc.subject.keywordAuthor | exo-polymer | - |
dc.subject.keywordAuthor | cytokine | - |
dc.subject.keywordAuthor | NK cell | - |
dc.subject.keywordAuthor | tumor metastasis | - |
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