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Chromofluorescent indicator for intracellular Zn2+/Hg2+ dynamic exchange
- Authors
- Lee, Jeong Won; Jung, Hyo Sung; Kwon, Pil Seung; Kim, Jong Wan; Bartsch, Richard A.; Kim, Youngmee; Kim, Sung-Jin; Kim, Jong Seung
- Issue Date
- 4-9월-2008
- Publisher
- AMER CHEMICAL SOC
- Citation
- ORGANIC LETTERS, v.10, no.17, pp.3801 - 3804
- Indexed
- SCIE
SCOPUS
- Journal Title
- ORGANIC LETTERS
- Volume
- 10
- Number
- 17
- Start Page
- 3801
- End Page
- 3804
- ISSN
- 1523-7060
- Abstract
- The fluorescence of NABQ increases remarkably in the presence of Zn2+ and is quenched by Hg2+. As shown by confocal imaging, NABQ-Zn2+ can penetrate cells, where the bound Zn2+ is exchanged for Hg2+. This results in the concomitant export of Hg2+ from the cells, showing that NABO can act as a Zn2+ carrier and as a Hg2+ extracting agent in living cells.
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