Occurrence and mechanisms of amikacin resistance and its association with beta-lactamases in Pseudomonas aeruginosa: a Korean nationwide study
DC Field | Value | Language |
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dc.contributor.author | Kim, Ja-Young | - |
dc.contributor.author | Park, Yeon-Joon | - |
dc.contributor.author | Kwon, Hi Jeong | - |
dc.contributor.author | Han, Kyungja | - |
dc.contributor.author | Kang, Moon Won | - |
dc.contributor.author | Woo, Gun-Jo | - |
dc.date.accessioned | 2021-09-09T04:45:00Z | - |
dc.date.available | 2021-09-09T04:45:00Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-09 | - |
dc.identifier.issn | 0305-7453 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/122785 | - |
dc.description.abstract | Objectives: We investigated the occurrence and mechanism of amikacin resistance and its association with various beta-lactamase genes in Pseudomonas aeruginosa isolates. Methods: Of the total 250 consecutive, non-duplicated isolates of P. aeruginosa, 55 isolates showed amikacin resistance. PCR amplification of genes for aminoglycoside (AG)-modifying enzymes [aac(3)-I, aac(3)-II/VI, aac(3)-III/IV, aac(6')-I, aac(6')-II, ant(2 '')-I, ant(4')-II and aph(3')-VI], 16S rRNA methylases (rmtA, rmtB, rmtC and armA) and class 1 integrons was performed. In addition, we analysed the association of AG resistance genes with various beta-lactamase genes. Results and conclusions: In Korea, the amikacin resistance rate in P. aeruginosa was high (22%), and it varied among provinces (3.8% to 40%). Four types of AG-modifying enzyme genes [aph(3')-VI, ant(2 '')-I, aac(6')-I and aac(3)-II/VI] were found in 48 isolates. Thirty-six strains harboured two or more types of enzymes, of which a combination of aph(3')-VI and ant(2 '')-I was the most frequent (24/36 isolates, 66.7%). None harboured aac(3)-I, aac(3)-III/IV, aac(6')-II, ant(4')-II, rmtA, rmtB, rmtC or armA. Forty-two isolates co-harboured beta-lactamase genes (mostly bla(OXA-10)). A class 1 integron was detected in all but one, and all the ant(2 '')-I and 26/29 bla(OXA-10) were found in it. In contrast, aph(3')-VI was not found to be associated with the class 1 integron. Considering the possibility of co-selection and dissemination, constant monitoring of resistance evolution is necessary. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.subject | AMINOGLYCOSIDE RESISTANCE | - |
dc.subject | CLASS-A | - |
dc.subject | PREVALENCE | - |
dc.subject | GENE | - |
dc.title | Occurrence and mechanisms of amikacin resistance and its association with beta-lactamases in Pseudomonas aeruginosa: a Korean nationwide study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Woo, Gun-Jo | - |
dc.identifier.doi | 10.1093/jac/dkn244 | - |
dc.identifier.scopusid | 2-s2.0-49649093171 | - |
dc.identifier.wosid | 000258473200010 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, v.62, no.3, pp.479 - 483 | - |
dc.relation.isPartOf | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | - |
dc.citation.title | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | - |
dc.citation.volume | 62 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 479 | - |
dc.citation.endPage | 483 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | AMINOGLYCOSIDE RESISTANCE | - |
dc.subject.keywordPlus | CLASS-A | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | aminoglycoside-modifying enzymes | - |
dc.subject.keywordAuthor | aph(3 &apos | - |
dc.subject.keywordAuthor | )-VI | - |
dc.subject.keywordAuthor | beta-lactamases | - |
dc.subject.keywordAuthor | integrons | - |
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