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Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling
- Authors
- Jeon, Hye-Min; Jin, Xun; Lee, Joong-Seob; Oh, Se-Yeong; Sohn, Young-Woo; Park, Hyo-Jung; Joo, Kyeung Min; Park, Woong-Yang; Nam, Do-Hyun; DePinho, Ronald A.; Chin, Lynda; Kim, Hyunggee
- Issue Date
- 1-8월-2008
- Publisher
- COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
- Keywords
- Id4; Ink4a/Arf(-/-) astrocyte; notch signaling; cyclin E; neural stem-like cells; glioblastoma
- Citation
- GENES & DEVELOPMENT, v.22, no.15, pp.2028 - 2033
- Indexed
- SCIE
SCOPUS
- Journal Title
- GENES & DEVELOPMENT
- Volume
- 22
- Number
- 15
- Start Page
- 2028
- End Page
- 2033
- ISSN
- 0890-9369
- Abstract
- Cellular origins and genetic factors governing the genesis and maintenance of glioblastomas (GBM) are not well understood. Here, we report a pathogenetic role of the developmental regulator Id4 (inhibitor of differentiation 4) in GBM. In primary murine Ink4a/Arf(-/)-astrocytes, and human glioma cells, we provide evidence that enforced Id4 can drive malignant transformation by stimulating increased cyclin E to produce a hyperproliferative profile and by increased Jagged1 expression with Notch1 activation to drive astrocytes into a neural stem-like cell state. Thus, Id4 plays an integral role in the transformation of astrocytes via its combined actions on two-key cell cycle and differentiation regulatory molecules.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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