Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Experimental pulmonary fat embolism: Computed tomography and Pathologic findings of the sequential changes

Authors
Woo, Ok HeeYong, Hwan SeokOh, Yu-WhanShin, Bong KyungKim, Han KyeomKang, Eun-Young
Issue Date
8월-2008
Publisher
KOREAN ACAD MEDICAL SCIENCES
Keywords
embolism; experimental studies; embolism; fat; pulmonary embolism; lung; computed tomography
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.23, no.4, pp.691 - 699
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume
23
Number
4
Start Page
691
End Page
699
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/122941
DOI
10.3346/jkms.2008.23.4.691
ISSN
1011-8934
Abstract
This study was done to demonstrate the computed tomography (CT) and pathologic findings of the sequential changes for experimental pulmonary fat embolism (PFE), and to correlate the CT and pathologic findings of rabbit lung. PFE was induced by an intravenous injection of 0.2 mL linoleic acid in 24 rabbits. The rabbits were divided into 4 groups of 6 rabbits each. CT scans were obtained sequentially at 2 hr (n=24), day 1 (n=18), day 3 (n=12) and day 7 (n=6) after fat embolization. The pathologic findings were analyzed and CT-pathologic correlation was done. CT scans showed bilateral ground-glass opacity (GGO), consolidation and nodule in all cases. The findings of PFE at 2 hr after fat embolization were areas of decreased attenuation, GGO, consolidation and nodule. These findings were aggravated on the follow-up CT after 1 day and 3 days. The follow-up CT revealed linear density in the subpleural lungs after 7 days. On CT-pathology correlation, wedge-shaped ischemic necrosis in, the subpleural lungs correlated with nodule at 2 hr. GGO and consolidation at day 1 on CT correlated with congestion and edema, and these findings at day 3 were correlated with inflammation and hemorrhagic edema. The linear density in the subpleural lungs correlated with interstitial fibrosis and pleural contraction at day 7. In conclusion, PFE was caused by using linoleic acid which is kind of free fatty acid and this study served as one model of the occurrence of nontraumatic PFE. CT accurately depicted the natural evolution of PFE in the serial followup, and this correlated well with the pathologic findings.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Oh, Yu Whan photo

Oh, Yu Whan
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE