Simvastatin prevents oxygen and glucose deprivation/reoxygenation-induced death of cortical neurons by reducing the production and toxicity of 4-hydroxy-2E-nonenal
- Authors
- Lim, JH; Lee, JC; Lee, YH; Choi, IY; Oh, YK; Kim, HS; Park, JS; Kim, WK
- Issue Date
- 4월-2006
- Publisher
- WILEY
- Keywords
- 4-hydroxy-2E-nonenal; ischemia; nuclear factor-kappa B; simvastatin
- Citation
- JOURNAL OF NEUROCHEMISTRY, v.97, no.1, pp.140 - 150
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NEUROCHEMISTRY
- Volume
- 97
- Number
- 1
- Start Page
- 140
- End Page
- 150
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/123145
- DOI
- 10.1111/j.1471-4159.2006.03715.x
- ISSN
- 0022-3042
- Abstract
- Lipid membrane peroxidation is highly associated with neuronal death in various neurodegenerative diseases including cerebral stroke. Here, we report that simvastatin decreases oxygen and glucose deprivation (OGD)/reoxygenation-evoked neuronal death by inhibiting the production and cytoxicity of 4-hydroxy-2E-nonenal (HNE), the final product of lipid peroxidation. Simvastatin markedly decreased the OGD/reoxygenation-evoked death of cortical neurons. OGD/reoxygenation increased the intracellular HNE level mostly in neuronal cells, not glial cells. Simvastatin decreased the intracellular level of HNE in neuronal cells exposed to OGD/reoxygenation. We further found that HNE induced the cytotoxicity in neuronal cells and synergistically increased the N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity. Simvastatin largely blocked the NMDA neurotoxicity potentiated by HNE. However, simvastatin did not alter the NMDA-evoked calcium influx in the absence or presence of HNE. HNE inhibited the activity of nuclear factor-kappa B (NF-kappa B), and the cytotoxicity of HNE was in good correlation with inactivation of NF-kappa B. Simvastatin reversed the inhibition of NF-kappa B activity induced by OGD/reoxygenation or HNE. The neuroprotection by simvastatin was significantly attenuated by various NF-kappa B inhibitors, implying that simvastatin inhibits the cytotoxicity of HNE at least in part by maintaining the activity of NF-kappa B. Further understanding of the neuroprotective mechanism of simvastatin may provide a therapeutic strategy for oxidative stress-related neurodegenerative diseases.
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