DNA damage in T and B lymphocytes, bone marrow, spleens, and livers of rats exposed to benzene
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, E | - |
dc.contributor.author | Im, H | - |
dc.contributor.author | Oh, E | - |
dc.contributor.author | Jung, WW | - |
dc.contributor.author | Kang, HS | - |
dc.contributor.author | Sul, D | - |
dc.date.accessioned | 2021-09-09T06:51:36Z | - |
dc.date.available | 2021-09-09T06:51:36Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2005-06 | - |
dc.identifier.issn | 0895-8378 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/123235 | - |
dc.description.abstract | Single-cell gel electrophoresis assays were performed in order to evaluate DNA damage occurring in the T and B lymphocytes, spleens, bone marrow, and livers of rats exposed to benzene at a concentration of 100, 200, or 400 ppm for 2 or 4 wk. The level of t,t-muconic acid (t,t-MA), which is a urinary benzene metabolite, was determined. In the control rats, mean Olive tail moments in the T and B lymphocytes were 1.507 +/- 0.398 and 1.579 +/- 0.206, respectively. DNA damage in the T and B lymphocytes exposed to 400 ppm benzene for 4 wk caused those rats to exhibit the highest Olive tail moments, with their values measured as 4.351 +/- 0.510 and 3.140 +/- 0.631, respectively. Also, the t,t-MA levels increased directly with increasing benzene exposure time and dose during the 4 wk. After 4 wk, the levels of t,t-MA in urine from rats exposed to 100, 200, and 400 ppm were 19.30 +/- 5.62, 30.36 +/- 4.46, and 46.93 +/- 9.10 mg/g creatinine. In conclusion, the present study demonstrates that benzene exposure results in significant DNA damage in the T and B lymphocytes, bone marrow, spleens, and livers of rats. DNA damage in the blood cells and organs was also discovered to vary directly with benzene exposure, in both a dose-dependent and time-dependent manner. In addition, a similar trend regarding DNA damage was found in the blood cells and organs, and evidenced a good association with the level of t,t-MA in the urine. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | CELL GEL-ELECTROPHORESIS | - |
dc.subject | TISSUE DISTRIBUTION | - |
dc.subject | FREE-RADICALS | - |
dc.subject | MICE | - |
dc.subject | METABOLISM | - |
dc.subject | INHALATION | - |
dc.subject | ADDUCTS | - |
dc.subject | CARCINOGENICITY | - |
dc.subject | HEMATOTOXICITY | - |
dc.subject | GENOTOXICITY | - |
dc.title | DNA damage in T and B lymphocytes, bone marrow, spleens, and livers of rats exposed to benzene | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sul, D | - |
dc.identifier.doi | 10.1080/08958370590929529 | - |
dc.identifier.scopusid | 2-s2.0-21344437741 | - |
dc.identifier.wosid | 000229006300006 | - |
dc.identifier.bibliographicCitation | INHALATION TOXICOLOGY, v.17, no.7-8, pp.401 - 408 | - |
dc.relation.isPartOf | INHALATION TOXICOLOGY | - |
dc.citation.title | INHALATION TOXICOLOGY | - |
dc.citation.volume | 17 | - |
dc.citation.number | 7-8 | - |
dc.citation.startPage | 401 | - |
dc.citation.endPage | 408 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | CELL GEL-ELECTROPHORESIS | - |
dc.subject.keywordPlus | TISSUE DISTRIBUTION | - |
dc.subject.keywordPlus | FREE-RADICALS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | INHALATION | - |
dc.subject.keywordPlus | ADDUCTS | - |
dc.subject.keywordPlus | CARCINOGENICITY | - |
dc.subject.keywordPlus | HEMATOTOXICITY | - |
dc.subject.keywordPlus | GENOTOXICITY | - |
dc.subject.keywordAuthor | DNA damage | - |
dc.subject.keywordAuthor | benzene | - |
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