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P19 Embryonal carcinoma cells: a new model for the study of endothelial cell differentiation
- Issue Date
- 7월-2008
- Publisher
- SPRINGER
- Keywords
- carcinoma cells; dimethyl sulphoxide; embryoid body; endothelial cell differentiation; P19 embryonal carcinoma cells; vascular endothelial growth factor
- Citation
- BIOTECHNOLOGY LETTERS, v.30, no.7, pp.1169 - 1175
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOTECHNOLOGY LETTERS
- Volume
- 30
- Number
- 7
- Start Page
- 1169
- End Page
- 1175
- ISSN
- 0141-5492
- Abstract
- P19 embryonal carcinoma cells were examined under different conditions of embryoid body (EB) formation to evaluate endothelial differentiation. A prominent capillary-like network including PECAM-1 positive cells and upregulated expression of endothelial markers Tie-1, Tie-2, Flk-1 and PECAM-1 were identified in the DMSO-treated group during EB formation as well as after VEGF treatment. About 4% of the P19 cells differentiated into PECAM-1 positive cells on day 14 of differentiation. These results suggest that the P19 cells have the potential for endothelial cell differentiation and provide a new model system for future research.
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