Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Bone morphogenetic protein-2 enhances bone regeneration mediated by transplantation of osteogenically undifferentiated bone marrow-derived mesenchymal stem cells

Authors
Kang, Sun-WoongLa, Wan-GeunKang, Jin MukPark, Jung-HoKim, Byung-Soo
Issue Date
Jul-2008
Publisher
SPRINGER
Keywords
bone marrow-derived stem cell; bone morphogenetic protein-2; bone regeneration; tissue engineering
Citation
BIOTECHNOLOGY LETTERS, v.30, no.7, pp.1163 - 1168
Indexed
SCIE
SCOPUS
Journal Title
BIOTECHNOLOGY LETTERS
Volume
30
Number
7
Start Page
1163
End Page
1168
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/123288
DOI
10.1007/s10529-008-9675-8
ISSN
0141-5492
Abstract
We have hypothesized that human bone marrow-derived mesenchymal stem cells (BMMSCs), that are not osteogenically differentiated prior to implantation, would regenerate bone extensively in vivo once exogenous bone morphogenetic protein-2 (BMP-2) was delivered to the implantation site. BMP-2 released from heparin-conjugated poly(lactic-co-glycolic acid) (HCPLGA) scaffolds stimulates osteogenic differentiation of cultured BMMSCs. Upon implantation, undifferentiated BMMSCs on BMP-2-loaded HCPLGA scaffolds induce far more extensive bone formation than either undifferentiated BMMSCs or osteogenically differentiated BMMSCs on HCPLGA scaffolds. These BMP-2-loaded HCPLGA scaffolds could prove invaluable for in vivo regeneration of bone from undifferentiated human BMMSCs.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Park, Jung Ho photo

Park, Jung Ho
College of Medicine (Department of Medical Science)
Read more

Altmetrics

Total Views & Downloads

BROWSE