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Bone morphogenetic protein-2 enhances bone regeneration mediated by transplantation of osteogenically undifferentiated bone marrow-derived mesenchymal stem cells
- Issue Date
- 7월-2008
- Publisher
- SPRINGER
- Keywords
- bone marrow-derived stem cell; bone morphogenetic protein-2; bone regeneration; tissue engineering
- Citation
- BIOTECHNOLOGY LETTERS, v.30, no.7, pp.1163 - 1168
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOTECHNOLOGY LETTERS
- Volume
- 30
- Number
- 7
- Start Page
- 1163
- End Page
- 1168
- ISSN
- 0141-5492
- Abstract
- We have hypothesized that human bone marrow-derived mesenchymal stem cells (BMMSCs), that are not osteogenically differentiated prior to implantation, would regenerate bone extensively in vivo once exogenous bone morphogenetic protein-2 (BMP-2) was delivered to the implantation site. BMP-2 released from heparin-conjugated poly(lactic-co-glycolic acid) (HCPLGA) scaffolds stimulates osteogenic differentiation of cultured BMMSCs. Upon implantation, undifferentiated BMMSCs on BMP-2-loaded HCPLGA scaffolds induce far more extensive bone formation than either undifferentiated BMMSCs or osteogenically differentiated BMMSCs on HCPLGA scaffolds. These BMP-2-loaded HCPLGA scaffolds could prove invaluable for in vivo regeneration of bone from undifferentiated human BMMSCs.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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