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Induction of neural stem cell-like cells (NSCLCs) from mouse astrocytes by Bmi1

Authors
Moon, Jai-HeeYoon, Byung SunKim, BonaPark, GyumanJung, Hye-YounMaeng, IsaacJun, Eun KyoungYoo, Seung JunKim, AereeOh, SejongWhang, Kwang YounKim, HyunggeeKim, Dong-WookKim, Ki DongYou, Seungkwon
Issue Date
27-Jun-2008
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
neural stem cells; astrocytes; dedifferentiation; neural stem cell-like cells
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.371, no.2, pp 267 - 272
Pages
6
Indexed
SCIE
SCOPUS
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume
371
Number
2
Start Page
267
End Page
272
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/123354
DOI
10.1016/j.bbrc.2008.04.068
ISSN
0006-291X
1090-2104
Abstract
Recently, Bmi1 was shown to control the proliferation and self-renewal of neural stem cells (NSCs). In this study, we demonstrated the induction of NSC-like cells (NSCLCs) from mouse astrocytes by Bmi1 under NSC culture conditions. These NSCLCs exhibited the morphology and growth properties of NSCs, and expressed NSC marker genes, including nestin, CD133, and Sox2. In vitro differentiation of NSCLCs resulted in differentiated cell populations containing astrocytes, neurons, and oligodendrocytes. Following treatment with histone deacetylase inhibitors (trichostatin A and valproic acid), the potential of NSCLCs for proliferation, dedifferentiation, and self-renewal was significantly inhibited. Our data indicate that multipotent NSCLCs can be generated directly from astrocytes by the addition of Bmi1. (C) 2008 Elsevier Inc. All rights reserved.
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