ent-kaurane diterpenoids from Isodon japonicus
- Authors
- Hong, Seong Su; Lee, Seon A.; Han, Xiang Hua; Hwang, Ji Sang; Lee, Chul; Lee, Dongho; Hong, Jin Tae; Kim, Youngsoo; Lee, Heesoon; Hwang, Bang Yeon
- Issue Date
- 6월-2008
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.71, no.6, pp.1055 - 1058
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 71
- Number
- 6
- Start Page
- 1055
- End Page
- 1058
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/123414
- DOI
- 10.1021/np0705965
- ISSN
- 0163-3864
- Abstract
- Five ent-kaurane diterpenoids, 6 beta,7 beta, 14 beta-trihydroxy-1 alpha,19-diacetoxy-7 alpha,20-epoxy-ent-kaur-16-en-15-one (1), 1 alpha,6 beta,7 beta-trihydroxy-11 alpha,19-diacetoxy-7 alpha,20-epoxy-ent-kaur-16-en-15-one (2), 6-hydroxy-1 alpha,19-diacetoxy-6,7-seco-ent-kaur-16en-15-one-7,20-olide (3), 19-hydroxy-1 alpha,6-diacetoxy-6,7-seco-ent-kaur-16-en-15-one-7,20-olide (4), and 6-aldehyde-1 alpha,19-diacetoxy-6,7-seco-ent-kaur-16-en-15-one-7,20-olide (5), along with 10 known ent-kaurane diterpenoids, pseurata C (6), longikaurin C (7), effusanin C (8), longikaurin B (9), longikaurin D (10), effusanin D (11), excisanin B (12), lasiokaurin (13), megathyrin A (14), and loxothyrin A (15), were isolated from the aerial parts of Isodon japonicus. Their structures were determined on the basis of spectroscopic (1D-, 2D-NMR and MS) and chemical evidence. The isolates were evaluated for their inhibitory effects on LPS-induced production of nitric oxide in murine macrophage RAW264.7 cells.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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