Methylpiperate derivatives from Piper longum and their inhibition of monoamine oxidase
- Authors
- Lee, Seon A.; Hwang, Ji Sang; Han, Xiang Hua; Lee, Chul; Lee, Min Hee; Choe, Sang Gil; Hong, Seong Su; Lee, Dongho; Lee, Myung Koo; Hwang, Bang Yeon
- Issue Date
- Jun-2008
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Piper longum; Piperaceae; methylpiperate; monoamine oxidase inhibitor
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.31, no.6, pp.679 - 683
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 31
- Number
- 6
- Start Page
- 679
- End Page
- 683
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/123506
- DOI
- 10.1007/s12272-001-1212-7
- ISSN
- 0253-6269
- Abstract
- We have previously reported that piperine, a known piperidine alkaloid from Piper longum, competitively inhibited mouse brain MAO-A and MAO-B activities. Piperine also showed in vivo antidepressant-like activity against the tail suspension test. In the present study, we further expanded on the identification of MAO inhibitors from the fruit of R longum. Activity-guided fractionation of a methylene chloride soluble extract led to the isolation of three known piperine-related compounds, methylpiperate (1), guineensine (2), and piperlonguminine (3). Of these, methylpiperate (1) and guineensine (2) showed significant MAO inhibitory activities with IC50 values of 3.6 and 139.2 mu M, respectively. Furthermore, methylpiperate (1) exhibited a selective inhibitory effect against MAO-B (IC50 value: 1.6 mu M) than MAO-A (IC50 value: 27.1 mu M). The kinetic study using the Lineweaver-Burk plots analysis suggested that methylpiperate (1) competitively inhibits MAO-A and MAO-B activities with the Ki values of 23.5 and 1.3 mu M, respectively.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.