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Effects of methylphenidate and bupropion on DHEA-S and cortisol plasma levels in attention-deficit hyperactivity disorder
- Authors
- Lee, Moon-Soo; Yang, Jae-Won; Ko, Young-Hoon; Han, Changsu; Kim, Seung-Hyun; Lee, Min-Soo; Joe, Sook-Haeng; Jung, In-Kwa
- Issue Date
- Jun-2008
- Publisher
- SPRINGER
- Keywords
- attention deficit disorder with hyperactivity; dehydroepiandrosterone sulfate; methylphenidate; bupropion
- Citation
- CHILD PSYCHIATRY & HUMAN DEVELOPMENT, v.39, no.2, pp.201 - 209
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHILD PSYCHIATRY & HUMAN DEVELOPMENT
- Volume
- 39
- Number
- 2
- Start Page
- 201
- End Page
- 209
- ISSN
- 0009-398X
- Abstract
- We evaluated plasma levels of DHEA-S and cortisol before and after treating ADHD patients with one of two medications: methylphenidate (n = 12) or bupropion (n = 10). Boys with ADHD (combined type) were evaluated with the Korean ADHD rating scale (K-ARS) and the computerized ADHD diagnostic system (ADS). All assessments were measured at baseline and repeated after 12 weeks. There were significant clinical improvements in both treatment groups as measured by K-ARS and ADS. DHEA-S levels increased from baseline to endpoint, but cortisol levels did not change significantly. This study suggests that both methylphenidate and bupropion increase plasma levels of DHEA-S in boys with ADHD.
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Related Researcher
- Lee, Moon Soo
- College of Medicine (Department of Medical Science)