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Effects of methylphenidate and bupropion on DHEA-S and cortisol plasma levels in attention-deficit hyperactivity disorder

Authors
Lee, Moon-SooYang, Jae-WonKo, Young-HoonHan, ChangsuKim, Seung-HyunLee, Min-SooJoe, Sook-HaengJung, In-Kwa
Issue Date
6월-2008
Publisher
SPRINGER
Keywords
attention deficit disorder with hyperactivity; dehydroepiandrosterone sulfate; methylphenidate; bupropion
Citation
CHILD PSYCHIATRY & HUMAN DEVELOPMENT, v.39, no.2, pp.201 - 209
Indexed
SCIE
SCOPUS
Journal Title
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
Volume
39
Number
2
Start Page
201
End Page
209
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/123507
DOI
10.1007/s10578-007-0081-6
ISSN
0009-398X
Abstract
We evaluated plasma levels of DHEA-S and cortisol before and after treating ADHD patients with one of two medications: methylphenidate (n = 12) or bupropion (n = 10). Boys with ADHD (combined type) were evaluated with the Korean ADHD rating scale (K-ARS) and the computerized ADHD diagnostic system (ADS). All assessments were measured at baseline and repeated after 12 weeks. There were significant clinical improvements in both treatment groups as measured by K-ARS and ADS. DHEA-S levels increased from baseline to endpoint, but cortisol levels did not change significantly. This study suggests that both methylphenidate and bupropion increase plasma levels of DHEA-S in boys with ADHD.
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