Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Both plasma retinol-binding protein and haptoglobin precursor allele 1 in CSF: Candidate biomarkers for the progression of normal to mild cognitive impairment to Alzheimer's disease

Authors
Jung, Sang MinLee, KiBeomLee, JoungWookNamkoong, HongKim, Hyun KeeKim, SangheeNa, Hae RiHa, Seon-AhKim, Jae-RyongKo, JesangKim, Jin Woo
Issue Date
9-May-2008
Publisher
ELSEVIER IRELAND LTD
Keywords
cerebrospinal fluid; Alzheimer' s disease; biological markers; cognitive impairment; proteomics; plasma retinol-binding protein; haptoglobin precursor allele 1
Citation
NEUROSCIENCE LETTERS, v.436, no.2, pp.153 - 157
Indexed
SCIE
SCOPUS
Journal Title
NEUROSCIENCE LETTERS
Volume
436
Number
2
Start Page
153
End Page
157
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/123548
DOI
10.1016/j.neulet.2008.03.010
ISSN
0304-3940
Abstract
Cerebrospinal fluid (CSF) may be of valuable for exploring protein markers for the diagnosis of Alzheimer's disease (AD). The prospect of early detection and treatment, to slow progression, holds hope for aging populations with increased average lifespan. The aim of the present study was to investigate candidate CSF biological markers in patients with mild cognitive impairment (MCI) and AD and compare them with age-matched normal control subjects. In this report, we applied proteomics approaches to analyze 60 CSF samples derived from patients with neurodegenerative diseases such as MCI and AD. We classified patients by three groups: normal controls without cognitive dysfunction, MCI and AD. The AD group was subdivided into three groups by clinical severity according to clinical dementia rating (CDR), a well known clinical scale for dementia. We demonstrated a gradual decrease or absent of plasma retinol-binding protein (RBP) and haptoglobin precursor allele I in CSF from patients with MCI and AD compared to the age-matched normal subjects. Moreover, expression levels of both RBP and haptoglobin precursor allele 1 were observed to be very high in age-matched normal subjects. In contrast, the RBP and haptoglobin precursor allele 1 were much decreased in the MCI group; those expressions were more weak or absent in AD group, and correlated with disease severity and progression. These findings suggest that the CSF levels of both RBP and haptoglobin precursor allele 1 may be candidate biomarkers for the progression of normal to MCI to AD. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Life Sciences > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher KO, JE SANG photo

KO, JE SANG
College of Life Sciences and Biotechnology (Division of Life Sciences)
Read more

Altmetrics

Total Views & Downloads

BROWSE