Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Critical role for Romo1-derived ROS in cell proliferation

Authors
Na, Ah RamChung, Young MinLee, Seung BaekPark, Seon HoLee, Myeong-SokYoo, Young Do
Issue Date
2-May-2008
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
reactive oxygen species; Romo1; hydrogen peroxide; cell proliferation; ERK
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.369, no.2, pp.672 - 678
Indexed
SCIE
SCOPUS
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume
369
Number
2
Start Page
672
End Page
678
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/123553
DOI
10.1016/j.bbrc.2008.02.098
ISSN
0006-291X
Abstract
Low levels of endogenous reactive oxygen species (ROS) originating from NADPH oxidase have been implicated in various signaling pathways induced by growth factors and mediated by cytokines. However, the main source of ROS is known to be the mitochondria, and increased levels of ROS from the mitochondria have been observed in many cancer cells. Thus far, the mechanism of ROS production in cancer cell proliferation in the mitochondria is not well-understood. We recently identified a novel protein, ROS modulator 1 (Romo1), and reported that increased expression of Romo1-triggered ROS production in the mitochondria. The experiments conducted in the present study showed that Romo1-derived ROS were indispensable for the proliferation of both normal and cancer cells. Furthermore, whilst cell growth was inhibited by blocking the ERK pathway in cells transfected with siRNA directed against Romo1, the cell growth was recovered by addition of exogenous hydrogen peroxide. The results of this study suggest that Romo1-induced ROS may play an important role in redox signaling in cancer cells. (c) 2008 Elsevier Inc. All rights reserved.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Medicine > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Yoo, Young Do photo

Yoo, Young Do
College of Medicine (Department of Medical Science)
Read more

Altmetrics

Total Views & Downloads

BROWSE