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Genetic analysis of HAV strains isolated from patients with acute hepatitis in Korea, 2005-2006

Authors
Yun, HaesunKim, SoyeonLee, HyeokjinByun, Kwan SooKwon, SoYoungYim, Hyung JoonLim, Young-SukJeong, Sook-HyangJee, Youngmee
Issue Date
May-2008
Publisher
WILEY-LISS
Keywords
hepatitis A virus; acute hepatitis A; genetic analysis; genotype
Citation
JOURNAL OF MEDICAL VIROLOGY, v.80, no.5, pp.777 - 784
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF MEDICAL VIROLOGY
Volume
80
Number
5
Start Page
777
End Page
784
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/123653
DOI
10.1002/jmv.21127
ISSN
0146-6615
Abstract
Hepatitis A virus (HAV) is a causative agent of acute viral hepatitis, which represents a significant public health problem. HAV is usually transmitted by oral-fecal route and prevalent not only in developing countries but also in developed countries worldwide. To characterize the HAV wild type strains circulating in Korea, the VP3/VP1 and VP1/P2A junction regions were detected by RT-PCR from HAV IgM positives during 2005 and 2006. Among 160 HAV IgM positive sera, 30% (n = 48) were positive for HAV RNA. Additionally, the VP3/VP1 junction regions were detected all six stools, which collected from outbreak in Gyeonggi province. Phylogenetic analysis of the sequences obtained from 54 distinct HAV isolates revealed that most of the strains (n = 45) belonged to genotype IA and the others including nine strains belonged to genotype IIIA. Interestingly, a Q --> S amino acid change was dominantly observed at position 810 of the VP1/P2A junction region in 14 isolates. The molecular epidemiology of HAV infection in Korea has changed with the co-circulation of at least two genotypes and 810Q --> S amino acid substitutions were found to be prevalent. These results strongly suggest that various HAV strains, including genotype IIIA, might be imported from high-endemic countries into Korea. J. Med. Virol. 80:777-784,2008. (C) 2008 Wiley-Liss, Inc.
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