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Hypoxia-inducible factor-1 and nuclear factor-kappa B inhibitory meroterpene analogues of bakuchiol, a constituent of the seeds of Psoralea corylifolia
- Authors
- Wu, Cheng-Zhu; Hong, Seong Su; Cai, Xing Fu; Dat, Nguyen Tien; Nan, Ji-Xing; Hwang, Bang Yeon; Lee, Jung Joon; Lee, Dongho
- Issue Date
- 15-Apr-2008
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Psoralea corylifolia; Fabaceae; meroterpenoids; hypoxiainducible; factor-1; nuclear factor kappa B
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.18, no.8, pp.2619 - 2623
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 18
- Number
- 8
- Start Page
- 2619
- End Page
- 2623
- ISSN
- 0960-894X
- Abstract
- Two new meroterpenoids, 12,13-dihydro-12,13-dihydroxybakuchiol (2) and (12'S)-bisbakuchiol C (3), were isolated from the seeds of Psoralea corylifolia L. (Fabaceae). The structures of 2 and 3 were elucidated by spectroscopic and chemical methods. Six meroterpenoids isolated from P. corylifolia and three semi-synthetic analogues were evaluated for HIF-1 and NF-kappa B inhibition, and O-methyl and O-ethylbakuchiols (6 and 7) inhibited HIF-1 and NF-kappa B activation without significantly decreasing the viability of the AGS and HeLa cells, respectively. (c) 2008 Elsevier Ltd. All rights reserved.
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Related Researcher
- Lee, Dong ho
- Department of Plant Biotechnology