Synthesis of DAAS derivatives and their enhancement of HL-60 leukemia cell differentiation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Seung Hyun | - |
dc.contributor.author | Chung, Sun Young | - |
dc.contributor.author | Kim, Young Wall | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.contributor.author | Choi, Bo Gil | - |
dc.date.accessioned | 2021-09-09T10:40:04Z | - |
dc.date.available | 2021-09-09T10:40:04Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-03 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/123954 | - |
dc.description.abstract | DAAS is the diacetoxy acetal derivative of a-santonin and induces HL-60 cell differentiation into granulocytes. In this report, we investigated the structure-activity relationship (SAR) of DAAS derivatives in the differentiation of human HL-60 leukemia cells. Although its derivatives themselves had less effect on HL-60 cell differentiation than DAAS, the monoacetyl derivative, 2, mainly induced HL-60 cell differentiation. Moreover, compound 2 synergistically enhanced all-trans retinoic acid(ATRA)-induced HL-60 cell differentiation when combined with 50 nM ATRA, a well-known differentiation inducer. This enhancing effect is similar to that of DAAS in ATRA-induced differentiation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | INDUCTION | - |
dc.subject | SANTONIN | - |
dc.subject | ACID | - |
dc.title | Synthesis of DAAS derivatives and their enhancement of HL-60 leukemia cell differentiation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Seung Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Tae Sung | - |
dc.identifier.doi | 10.1007/s12272-001-1155-z | - |
dc.identifier.scopusid | 2-s2.0-46249096032 | - |
dc.identifier.wosid | 000254083000005 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.31, no.3, pp.300 - 304 | - |
dc.relation.isPartOf | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 31 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 300 | - |
dc.citation.endPage | 304 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001240294 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | SANTONIN | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordAuthor | DAAS | - |
dc.subject.keywordAuthor | santonin | - |
dc.subject.keywordAuthor | leukemia cell differentiation | - |
dc.subject.keywordAuthor | ATRA | - |
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