Synthesis of DAAS derivatives and their enhancement of HL-60 leukemia cell differentiation
- Authors
- Kim, Seung Hyun; Chung, Sun Young; Kim, Young Wall; Kim, Tae Sung; Choi, Bo Gil
- Issue Date
- 3월-2008
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- DAAS; santonin; leukemia cell differentiation; ATRA
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.31, no.3, pp.300 - 304
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 31
- Number
- 3
- Start Page
- 300
- End Page
- 304
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/123954
- DOI
- 10.1007/s12272-001-1155-z
- ISSN
- 0253-6269
- Abstract
- DAAS is the diacetoxy acetal derivative of a-santonin and induces HL-60 cell differentiation into granulocytes. In this report, we investigated the structure-activity relationship (SAR) of DAAS derivatives in the differentiation of human HL-60 leukemia cells. Although its derivatives themselves had less effect on HL-60 cell differentiation than DAAS, the monoacetyl derivative, 2, mainly induced HL-60 cell differentiation. Moreover, compound 2 synergistically enhanced all-trans retinoic acid(ATRA)-induced HL-60 cell differentiation when combined with 50 nM ATRA, a well-known differentiation inducer. This enhancing effect is similar to that of DAAS in ATRA-induced differentiation.
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