Evolution of VX2 carcinoma in rabbit tibia: magnetic resonance imaging with pathologic correlation
- Authors
- Choi, Jung-Ah; Kang, Eun Young; Kim, Han Kyeorn; Song, In Chan; Kim, Young I. I.; Kang, Heung Sik
- Issue Date
- 3월-2008
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- bone neoplasms, diagnosis; bone neoplasms, MR; magnetic resonance (MR), contrast enhancement; magnetic resonance (MR), experimental
- Citation
- CLINICAL IMAGING, v.32, no.2, pp.128 - 135
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL IMAGING
- Volume
- 32
- Number
- 2
- Start Page
- 128
- End Page
- 135
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/123959
- DOI
- 10.1016/j.clinimag.2007.08.021
- ISSN
- 0899-7071
- Abstract
- Objective: To evaluate the evolution of a metastatic bone tumor model with MRI-pathology correlation. Materials and Methods: VX2 carcinoma was implanted into the tibiae of 20 rabbits. The rabbits were divided into four groups of five (Groups I-IV). MRI was repeated at 1-week interval up to the fourth week, including sagittal T1-weighted image (T1WI), T2-weighted image (T2WI), gadolinium-enhanced fat-suppressed T1WI (GdT1WI), and diffusion-weighted image (DWI). Each group was sacrificed after the imaging, then histological examination for the tibiae with an implanted tumor was performed and MRI-pathologic correlation was done. Results: On MRI-pathology correlation, the corresponding findings were as follows; low SI on T1WI, T2WI-tumor cells, fibrosis (I week); central low SI on T1WI, T2WI, GdT1WI -tumor cells with fibrosis and necrosis; peripheral high SI on T2WI, DWI, GdT1WI-edema, fibrosis (2 weeks); heterogeneous SI with central low SI on T2WI, DWI-tumor cell nests with extensive necrosis, fibrosis; high SI on T2WI along periosteum-periosteal reaction; high SI around low SI and in bone marrow on T2WI, DWI, GdT1WI-edema, fibrosis; low SI on T1WI in surrounding bone marrow-tumor extension (3-4 weeks). Conclusion: The evolution of VX2 carcinoma model was well depicted on MR imaging. Necrosis and extent of tumor were best depicted on enhanced, fat-suppressed T1-weighted images. Heterogeneity of the tumor, peripheral edema, and fibrosis were represented well on T2-weighted images. Diffusion-weighted imaging could have a role in depicting necrosis in the evaluation of bone tumor. (C) 2008 Elsevier Inc. All rights reserved.
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