Anti-tumor immunostimulatory effect of heat-killed tumor cells
- Authors
- Yoon, Taek Joon; Kim, Ji Yeon; Kim, Hyojeong; Hong, Changwan; Lee, Hyunji; Lee, Chang-Kwon; Lee, Kwang Ho; Hong, Seokmann; Park, Se-Ho
- Issue Date
- 29-2월-2008
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- cancer vaccines; dendritic cells; immunotherapy; active; interleukin 12; mice
- Citation
- EXPERIMENTAL AND MOLECULAR MEDICINE, v.40, no.1, pp.130 - 144
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- EXPERIMENTAL AND MOLECULAR MEDICINE
- Volume
- 40
- Number
- 1
- Start Page
- 130
- End Page
- 144
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/124050
- DOI
- 10.3858/emm.2008.40.1.130
- ISSN
- 1226-3613
- Abstract
- As a part of our ongoing search for a safe and efficient anti-tumor vaccine, we attempted to determine whether the molecular nature of certain tumor antigens would influence immune responses against tumor cells. As compared with freeze-thawed or formaldehyde-fixed tumor antigens, heat-denatured tumor antigens elicited profound anti-tumor immune responses and greatly inhibited the growth of live tumor cells. The heat-denatured tumor antigens induced a substantial increase in the anti-tumor CTL response in the absence of any adjuvant material. This response appears to be initiated by strong activation of the antigen-presenting cells, which may recognize heat-denatured protein antigens. Upon recognition of the heat-denatured tumor antigens, macrophages and dendritic cells were found to acutely upregulate the expression of co-stimulatory molecules such as B7.2, as well as the secretion of inflammatory cytokines such as IL-12 and TNF-alpha. The results of this study indicate that heat-denatured tumor extracts might elicit protective anti-tumor adaptive immune responses and also raise the possibility that a safe and efficient adjuvant-free tumor vaccine might be developed in conjunction with a dendritic cell-based tumor vaccine.
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Collections - Graduate School > Department of Life Sciences > 1. Journal Articles
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