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Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca2+-PKC alpha-ERK pathway
- Authors
- Park, Moon Ho; Lee, Dae Hie
- Issue Date
- 29-2월-2008
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- calcium; cell survival; endothelins; mitogen-activated protein kinase 1; neurons; protein kinase C
- Citation
- EXPERIMENTAL AND MOLECULAR MEDICINE, v.40, no.1, pp.92 - 97
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- EXPERIMENTAL AND MOLECULAR MEDICINE
- Volume
- 40
- Number
- 1
- Start Page
- 92
- End Page
- 97
- ISSN
- 1226-3613
- Abstract
- Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and ET-3) were added to HN33 (mouse hippocampal neuron X neuroblastoma) cells. Among the three types of ET, only ET-1 increased the intracellular calcium levels in a PLC. dependent manner with the induction of ERK 1/2 activation. As the result of ET-1 exposure, the survival rate of HN33 cells and the PKC alpha. translocation into the plasma membrane were increased. We suggest that ET-1 participated in the neuroprotective effect involving the calcium-PKC alpha-ERK1/2 pathway.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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