A chitosan hydrogel-based cancer drug delivery system exhibits synergistic antitumor effects by combining with a vaccinia viral vaccine
- Authors
- Han, Hee Dong; Song, Chung Kil; Park, Yong Sung; Noh, Kyung Hee; Kim, Jin Hee; Hwang, Taewon; Kim, Tae Woo; Shin, Byung Cheol
- Issue Date
- 28-2월-2008
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- hydrogel; doxorubicin; vaccinia vaccine; chemoimmunotherapy
- Citation
- INTERNATIONAL JOURNAL OF PHARMACEUTICS, v.350, no.1-2, pp.27 - 34
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Volume
- 350
- Number
- 1-2
- Start Page
- 27
- End Page
- 34
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/124059
- DOI
- 10.1016/j.ijpharm.2007.08.014
- ISSN
- 0378-5173
- Abstract
- Cancer treatment combining chemotherapy and immunotherapy has been vigorously exploited to further improve cancer therapeutic efficacy. This study investigated a new chemoimmunotherapy approach utilizing hydrogel as a local anti-cancer drug delivery system. Chitosan hydrogel containing doxorubicin (CH-DOX) and vaccinia virus vaccine expressing Sig/E7/LAMP-1 (Vac-Sig/E7/1-AMP-1) were used as chemoimmunotherapeutic agents. It was found that intratumoral injection of CH-DOX effectively inhibited tumor growth itself and, in addition, exhibited a synergistic antitumor effect in combination with a vaccinia virus-based vaccine. This combination did not decrease but rather increased the number of tumor-specific CD8(+)T cells primed by vaccinia virus-mediated vaccination; the resulting antitumor effects were further improved up to 60 days as compared with monotherapy after tumor challenge, and the survival of tumor-bearing mice was dramatically prolonged. This study is a pioneer report that demonstrates the use of a biodegradable hydrogel system as an anti-cancer drug delivery system for successful chemoimmunotherapy. It is hoped that, this study can provide a foundation for a rational approach to improve antitumor efficacy of chemoimmunotherapy. (c) 2007 Elsevier B.V. All rights reserved.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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