The significances of lymph node micrometastasis and its correlation with E-cadherin expression in pT1-T3N0 gastric adenocarcinoma
- Authors
- Kim, Jong-Han; Park, Joong-Min; Jung, Cheol-Woong; Park, Sung-Soo; Kim, Seung-Joo; Mok, Young-Jae; Kim, Chong-Suk; Chae, Yang-Suk; Bae, Jeoung-Won
- Issue Date
- 1-2월-2008
- Publisher
- WILEY
- Keywords
- gastric cancer; lymph node micrometastasis; E-cadherin
- Citation
- JOURNAL OF SURGICAL ONCOLOGY, v.97, no.2, pp.125 - 130
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF SURGICAL ONCOLOGY
- Volume
- 97
- Number
- 2
- Start Page
- 125
- End Page
- 130
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/124097
- DOI
- 10.1002/jso.20937
- ISSN
- 0022-4790
- Abstract
- Background: Recently, micrometastasis (MM) in the lymph node in gastric cancer has been detected by cytokeratin immunostaining. However, clinical significance of MM and its relationship with reduced expression of E-cadherin in primary lesion have not been well studied. Methods: The 4,990 lymph nodes from 184 pT1 similar to T3N0 patients from 1995 to 2000 at Korea University Hospital were immunostained with the anticytokeratin AE1/3 antibody for detection of micometastasis. The primary lesions were also immunostained for E-cadherin expression. Results: MM in the lymph node of gastric cancer was found in 131 (2.6%) of total dissected nodes, and 31 of 184 patients (16.8%) were shown to have MM. The MM was significantly correlated with the depth of invasion, tumor size, operation method, Lauren classification, lymphovascular invasion and loss of E-cadherin expression in primary tumor. On multivariate analysis, the independent risk factors for MM were the depth of invasion and loss of E-cadherin expression. The patients with MM had significantly lower 5-year overall and disease free survival rate than those without MM. Conclusion: Lymph node MM in histologically node-negative gastric cancer was significantly correlated with poor 5-year survival rate. The determination of E-cadherin expression in primary gastric tumor may be useful in prediction of the MM.
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