Melampolides from the leaves of Smallanthus sonchifolius and their inhibitory activity of LPS-induced nitric oxide production
DC Field | Value | Language |
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dc.contributor.author | Hong, Seong Su | - |
dc.contributor.author | Lee, Seon A. | - |
dc.contributor.author | Han, Xiang Hua | - |
dc.contributor.author | Lee, Min Hee | - |
dc.contributor.author | Hwang, Ji Sang | - |
dc.contributor.author | Park, Jeong Sook | - |
dc.contributor.author | Oh, Ki-Wan | - |
dc.contributor.author | Han, Kun | - |
dc.contributor.author | Lee, Myung Koo | - |
dc.contributor.author | Lee, Heesoon | - |
dc.contributor.author | Kim, Wook | - |
dc.contributor.author | Lee, Dongho | - |
dc.contributor.author | Hwang, Bang Yeon | - |
dc.date.accessioned | 2021-09-09T11:42:49Z | - |
dc.date.available | 2021-09-09T11:42:49Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-02 | - |
dc.identifier.issn | 0009-2363 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/124184 | - |
dc.description.abstract | Two new melampolide-type sesquiterpene lactones, 8 beta-epoxyangeloyloxy-9 alpha-ethoxy-14-oxo-acanthospermolide (1) and 8 beta-angeloyloxy-9 alpha-ethoxy-14-oxo-acanthospermolide (2), were isolated from the leaves of yacon [Smallanthus sonchifolia (POEPP. et ENDL.) H. Robinson] along with eleven known melampolides, allo-schkuhriolide (3), enhydrin (4), polymatin A (5), fluctuanin (6), 8 beta-angeloyloxy-9 alpha-acetoxy-14-oxo-acanthospermolide (7), 8 beta-angeloyloxy-14-oxo-acanthospermolide (8), 8 beta-methacryloyloxymelampolid-14-oic acid methyl ester (9), uvedalin (10), polymatin B (11), 8 beta-tigloyloxymelampolid-14-oic acid methyl ester (12), and sonchifolin (13). Their structures were established on the basis of spectroscopic evidence including 1D- and 2D-NMR experiments. All isolates were evaluated for inhibition of LPS-induced nitric oxide production in murine macrophage RAW 264.7 cells. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOC JAPAN | - |
dc.subject | OCCURRING TERPENE DERIVATIVES | - |
dc.subject | SESQUITERPENE LACTONES | - |
dc.subject | ACID-DERIVATIVES | - |
dc.subject | YACON | - |
dc.subject | IDENTIFICATION | - |
dc.subject | CONSTITUENTS | - |
dc.subject | ROOTS | - |
dc.title | Melampolides from the leaves of Smallanthus sonchifolius and their inhibitory activity of LPS-induced nitric oxide production | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Wook | - |
dc.identifier.doi | 10.1248/cpb.56.199 | - |
dc.identifier.scopusid | 2-s2.0-38849157957 | - |
dc.identifier.wosid | 000253844700013 | - |
dc.identifier.bibliographicCitation | CHEMICAL & PHARMACEUTICAL BULLETIN, v.56, no.2, pp.199 - 202 | - |
dc.relation.isPartOf | CHEMICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.title | CHEMICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.volume | 56 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 199 | - |
dc.citation.endPage | 202 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | OCCURRING TERPENE DERIVATIVES | - |
dc.subject.keywordPlus | SESQUITERPENE LACTONES | - |
dc.subject.keywordPlus | ACID-DERIVATIVES | - |
dc.subject.keywordPlus | YACON | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | ROOTS | - |
dc.subject.keywordAuthor | Smallanthus sonchifolius | - |
dc.subject.keywordAuthor | Asteraccae | - |
dc.subject.keywordAuthor | yacon | - |
dc.subject.keywordAuthor | melampolide | - |
dc.subject.keywordAuthor | sesquiterpene lactone | - |
dc.subject.keywordAuthor | nitric oxide production inhibitor | - |
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