Implication of lipocalin-2 and visfatin levels in patients with coronary heart disease
DC Field | Value | Language |
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dc.contributor.author | Choi, K. M. | - |
dc.contributor.author | Lee, J. S. | - |
dc.contributor.author | Kim, E. J. | - |
dc.contributor.author | Baik, S. H. | - |
dc.contributor.author | Seo, H. S. | - |
dc.contributor.author | Choi, D. S. | - |
dc.contributor.author | Oh, D. J. | - |
dc.contributor.author | Park, C. G. | - |
dc.date.accessioned | 2021-09-09T11:44:59Z | - |
dc.date.available | 2021-09-09T11:44:59Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-02 | - |
dc.identifier.issn | 0804-4643 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/124194 | - |
dc.description.abstract | Objectives: Visfatin and lipocalin-2 are novel adipokines associated with insulin resistance (IR) and obesity-related metabolic disorders. We compared lipocalin-2 and visfatin concentrations between patients with coronary heart disease (CHD) and control subjects and evaluated their association with cardiovascular risk factors. Methods: We examined serum visfatin, lipocalm-2 levels, and cardiovascular risk factors in 91 subjects (49 patients with angiographically confirmed CHD versus 42 age- and gender-matched control participants). Results: Circulating lipocalin-2 levels were significantly higher in patients with CHD compared with the control subjects (82.6 +/- 38.7 ng/ml versus 43.8 +/- 2 7.8 ng/ml; P < 0.001.). However, visfatin levels were not significantly different between patients with CHD and control subjects. Serum lipocalin-2 levels were positively associated with weight (r=0.26; P=0.036), fasting insulin (r=0.36; P=0.003), and IR (r=0.33: P=0.007), whereas these levels showed a negative correlation with high-density lipoprotein (HDL) cholesterol (r= -0.30; P=0.016) after adjustment for gender and body mass index. However, visfatin levels were not associated with any variables of the metabolic syndrome. The multiple regression analysis showed that lipocalin-2 levels were independently associated with HDL cholesterol and IR (R-2 = 0.199). Furthermore. the multiple logistic regression analysis showed that systolic blood pressure, IR, and lipocalin-2 levels were independently associated with CHD. Conclusions: Serum lipocalin-2 levels were significantly elevated in patients with CHD and were independently associated with CHD. The present findings suggest that the measurement of serum lipocalin-2 levels may be useful for assessing CHD risk. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BIOSCIENTIFICA LTD | - |
dc.subject | GELATINASE-ASSOCIATED LIPOCALIN | - |
dc.subject | C-REACTIVE PROTEIN | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | MYOCARDIAL-INFARCTION | - |
dc.subject | ARTERY-DISEASE | - |
dc.subject | ADIPONECTIN | - |
dc.subject | RISK | - |
dc.subject | RETINOL-BINDING-PROTEIN-4 | - |
dc.subject | EXPRESSION | - |
dc.subject | OBESITY | - |
dc.title | Implication of lipocalin-2 and visfatin levels in patients with coronary heart disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, K. M. | - |
dc.contributor.affiliatedAuthor | Kim, E. J. | - |
dc.contributor.affiliatedAuthor | Baik, S. H. | - |
dc.contributor.affiliatedAuthor | Seo, H. S. | - |
dc.contributor.affiliatedAuthor | Choi, D. S. | - |
dc.contributor.affiliatedAuthor | Oh, D. J. | - |
dc.contributor.affiliatedAuthor | Park, C. G. | - |
dc.identifier.doi | 10.1530/EJE-07-0633 | - |
dc.identifier.scopusid | 2-s2.0-38949127057 | - |
dc.identifier.wosid | 000253380800009 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF ENDOCRINOLOGY, v.158, no.2, pp.203 - 207 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF ENDOCRINOLOGY | - |
dc.citation.title | EUROPEAN JOURNAL OF ENDOCRINOLOGY | - |
dc.citation.volume | 158 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 203 | - |
dc.citation.endPage | 207 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | GELATINASE-ASSOCIATED LIPOCALIN | - |
dc.subject.keywordPlus | C-REACTIVE PROTEIN | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | ARTERY-DISEASE | - |
dc.subject.keywordPlus | ADIPONECTIN | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | RETINOL-BINDING-PROTEIN-4 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | OBESITY | - |
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