Implication of lipocalin-2 and visfatin levels in patients with coronary heart disease
- Authors
- Choi, K. M.; Lee, J. S.; Kim, E. J.; Baik, S. H.; Seo, H. S.; Choi, D. S.; Oh, D. J.; Park, C. G.
- Issue Date
- 2월-2008
- Publisher
- BIOSCIENTIFICA LTD
- Citation
- EUROPEAN JOURNAL OF ENDOCRINOLOGY, v.158, no.2, pp.203 - 207
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Volume
- 158
- Number
- 2
- Start Page
- 203
- End Page
- 207
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/124194
- DOI
- 10.1530/EJE-07-0633
- ISSN
- 0804-4643
- Abstract
- Objectives: Visfatin and lipocalin-2 are novel adipokines associated with insulin resistance (IR) and obesity-related metabolic disorders. We compared lipocalin-2 and visfatin concentrations between patients with coronary heart disease (CHD) and control subjects and evaluated their association with cardiovascular risk factors. Methods: We examined serum visfatin, lipocalm-2 levels, and cardiovascular risk factors in 91 subjects (49 patients with angiographically confirmed CHD versus 42 age- and gender-matched control participants). Results: Circulating lipocalin-2 levels were significantly higher in patients with CHD compared with the control subjects (82.6 +/- 38.7 ng/ml versus 43.8 +/- 2 7.8 ng/ml; P < 0.001.). However, visfatin levels were not significantly different between patients with CHD and control subjects. Serum lipocalin-2 levels were positively associated with weight (r=0.26; P=0.036), fasting insulin (r=0.36; P=0.003), and IR (r=0.33: P=0.007), whereas these levels showed a negative correlation with high-density lipoprotein (HDL) cholesterol (r= -0.30; P=0.016) after adjustment for gender and body mass index. However, visfatin levels were not associated with any variables of the metabolic syndrome. The multiple regression analysis showed that lipocalin-2 levels were independently associated with HDL cholesterol and IR (R-2 = 0.199). Furthermore. the multiple logistic regression analysis showed that systolic blood pressure, IR, and lipocalin-2 levels were independently associated with CHD. Conclusions: Serum lipocalin-2 levels were significantly elevated in patients with CHD and were independently associated with CHD. The present findings suggest that the measurement of serum lipocalin-2 levels may be useful for assessing CHD risk.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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