Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

T-type Ca2+ channels as therapeutic targets in the nervous system

Authors
Shin, Hee-SupCheong, Eun-JiChoi, SoonwookLee, JungryunNa, Heung Sik
Issue Date
2월-2008
Publisher
ELSEVIER SCI LTD
Citation
CURRENT OPINION IN PHARMACOLOGY, v.8, no.1, pp.33 - 41
Indexed
SCIE
SCOPUS
Journal Title
CURRENT OPINION IN PHARMACOLOGY
Volume
8
Number
1
Start Page
33
End Page
41
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/124202
DOI
10.1016/j.coph.2007.12.003
ISSN
1471-4892
Abstract
Low-voltage-activated calcium channels, also known as T-type calcium channels, are widely expressed in various types of neurons. In contrast to high-voltage-activated calcium channels which can be activated by a strong depolarization of membrane potential, T-type channels can be activated by a weak depolarization near the resting membrane potential once deinactivated by hyperpolarization, and therefore can regulate the excitability and electroresponsiveness of neurons under physiological conditions near resting states. Recently, the molecular diversity and functional multiplicity of T-type channels have been demonstrated through molecular genetic studies coupled with physiological and behavioral analysis. Understanding the functional consequences of modulation of each subtype of these channels in vivo could point to the right direction for developing therapeutic tools for relevant diseases.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE