DNA damage in T- and B-lymphocytes and granulocytes in emission inspection and incineration workers exposed to polycyclic aromatic hydrocarbons
DC Field | Value | Language |
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dc.contributor.author | Sul, D | - |
dc.contributor.author | Oh, E | - |
dc.contributor.author | Im, H | - |
dc.contributor.author | Yang, M | - |
dc.contributor.author | Kim, CW | - |
dc.contributor.author | Lee, E | - |
dc.date.accessioned | 2021-09-09T12:26:19Z | - |
dc.date.available | 2021-09-09T12:26:19Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2003-07-08 | - |
dc.identifier.issn | 1383-5718 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/124354 | - |
dc.description.abstract | In this study, we investigated by using comet assay the effects of polycyclic aromatic hydrocarbon (PAH) as a major factor on DNA damage of workers exposed to exhaust fumes. Twenty-four workers from three automobile emission inspection companies, 28 workers from a waste incinerating company, and 43 matched, unexposed healthy subjects were enrolled in the study. The mean values of 1-hydroxypyrene (1-OHP) in automobile emission inspection and waste incineration workers were 0.27 +/- 0.19 and 0.57 +/- 0.46 mumol/mol creatinine, respectively, and the mean values of 2-naphthol in automobile emission inspectors and waste incineration workers were 4.80 +/- 4.01 and 8.30 +/- 4.79 mol/mol creatinine, respectively. Significant difference in urinary metabolites, I-hydroxypyrene and 2-naphthol was found between smokers and non-smokers in exposed groups and it may be due to the amounts of smoking cigarettes. In T-lymphocytes, DNA damage in control subjects, emission inspection workers and incineration workers were 1.42 +/- 0.22, 1.41 +/- 0.22 and 1.76 +/- 0.27, respectively. DNA damage of B-lymphocytes in the three groups showed the most significant differences of three cell types. The tail moments of the B-lymphocytes of control subjects, emission inspection and incineration workers were 1.40 +/- 0.27,2.44 +/- 0.32 and 2.36 +/- 0.37, respectively. In granulocytes, DNA damage was also different, the tail moments being 2.72 +/- 0.59,3.32 +/- 0.38 and 2.85 +/- 0.49, respectively. Although 1-OHP and 2-naphthol levels were statistically increased in smokers in workers exposed to PAHs, exposed smoking and non-smoking workers did not show any significantly difference in terms of Olive tail moments. Our results suggest that PAH causes single strand DNA breakage in human T- and B-lymphocytes, and granulocytes. A comparison of DNA damage in three groups showed that B-lymphocytes are useful target in the biomonitoring of human exposure. (C) 2003 Elsevier Science B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | CELL GEL-ELECTROPHORESIS | - |
dc.subject | WHITE BLOOD-CELLS | - |
dc.subject | COMET ASSAY | - |
dc.subject | URINARY 1-HYDROXYPYRENE | - |
dc.subject | CHEMICAL MUTAGENS | - |
dc.subject | POLYMORPHISMS | - |
dc.subject | METABOLITES | - |
dc.subject | 2-NAPHTHOL | - |
dc.subject | GSTM1 | - |
dc.subject | BENZENE | - |
dc.title | DNA damage in T- and B-lymphocytes and granulocytes in emission inspection and incineration workers exposed to polycyclic aromatic hydrocarbons | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sul, D | - |
dc.identifier.doi | 10.1016/S1383-5718(03)00095-0 | - |
dc.identifier.scopusid | 2-s2.0-0038433255 | - |
dc.identifier.wosid | 000184025900012 | - |
dc.identifier.bibliographicCitation | MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, v.538, no.1-2, pp.109 - 119 | - |
dc.relation.isPartOf | MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | - |
dc.citation.title | MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | - |
dc.citation.volume | 538 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 109 | - |
dc.citation.endPage | 119 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | CELL GEL-ELECTROPHORESIS | - |
dc.subject.keywordPlus | WHITE BLOOD-CELLS | - |
dc.subject.keywordPlus | COMET ASSAY | - |
dc.subject.keywordPlus | URINARY 1-HYDROXYPYRENE | - |
dc.subject.keywordPlus | CHEMICAL MUTAGENS | - |
dc.subject.keywordPlus | POLYMORPHISMS | - |
dc.subject.keywordPlus | METABOLITES | - |
dc.subject.keywordPlus | 2-NAPHTHOL | - |
dc.subject.keywordPlus | GSTM1 | - |
dc.subject.keywordPlus | BENZENE | - |
dc.subject.keywordAuthor | comet assay | - |
dc.subject.keywordAuthor | dioxin | - |
dc.subject.keywordAuthor | creatinine | - |
dc.subject.keywordAuthor | lymphocytes | - |
dc.subject.keywordAuthor | 1-hydroxypyrene | - |
dc.subject.keywordAuthor | 2-naphthol | - |
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