Single strand DNA breaks in T- and B-lymphocytes and granulocytes in workers exposed to benzene
DC Field | Value | Language |
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dc.contributor.author | Sul, DG | - |
dc.contributor.author | Lee, D | - |
dc.contributor.author | Im, H | - |
dc.contributor.author | Oh, E | - |
dc.contributor.author | Kim, J | - |
dc.contributor.author | Lee, E | - |
dc.date.accessioned | 2021-09-09T12:30:54Z | - |
dc.date.available | 2021-09-09T12:30:54Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2002-08-05 | - |
dc.identifier.issn | 0378-4274 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/124380 | - |
dc.description.abstract | Comet assays were carried out to evaluate DNA damage in T- and B-lymphocytes and granulocytes from 41 workers exposed to benzene in a printing company and 41 unexposed donors. In T-lymphocytes, DNA damage was slightly higher in exposed workers than in controls. The tail moments in the two groups were 1.75 +/- 0.29 and 1.47 +/- 0.41, respectively (P < 0.0006). DNA damage of B-lymphocytes in the two groups showed the most significant difference among the three cell types. The tail moments were 3.86 +/- 0.71 and 1.51 +/- 0.39, respectively (P < 0.0001). In granulocytes, DNA damage was also different, the tail moments being 3.61 +/- 0.75 and 2.60 +/- 0.59, respectively (P < 0.0001). The comparison of DNA damage in both groups shows that B-lymphocytes could be a useful target in biomonitoring of human exposure to low levels of benzene. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | NON-HODGKINS-LYMPHOMA | - |
dc.subject | CELL GEL-ELECTROPHORESIS | - |
dc.subject | PERFUSED MOUSE-LIVER | - |
dc.subject | BONE-MARROW | - |
dc.subject | MICE | - |
dc.subject | DAMAGE | - |
dc.subject | METABOLITES | - |
dc.subject | INHALATION | - |
dc.subject | GENOTOXICITY | - |
dc.subject | INHIBITION | - |
dc.title | Single strand DNA breaks in T- and B-lymphocytes and granulocytes in workers exposed to benzene | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sul, DG | - |
dc.identifier.doi | 10.1016/S0378-4274(02)00167-4 | - |
dc.identifier.wosid | 000178323600012 | - |
dc.identifier.bibliographicCitation | TOXICOLOGY LETTERS, v.134, no.1-3, pp.87 - 95 | - |
dc.relation.isPartOf | TOXICOLOGY LETTERS | - |
dc.citation.title | TOXICOLOGY LETTERS | - |
dc.citation.volume | 134 | - |
dc.citation.number | 1-3 | - |
dc.citation.startPage | 87 | - |
dc.citation.endPage | 95 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | NON-HODGKINS-LYMPHOMA | - |
dc.subject.keywordPlus | CELL GEL-ELECTROPHORESIS | - |
dc.subject.keywordPlus | PERFUSED MOUSE-LIVER | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | METABOLITES | - |
dc.subject.keywordPlus | INHALATION | - |
dc.subject.keywordPlus | GENOTOXICITY | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordAuthor | comet assay | - |
dc.subject.keywordAuthor | t,t-MA | - |
dc.subject.keywordAuthor | creatinine | - |
dc.subject.keywordAuthor | lymphocytes | - |
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