Single strand DNA breaks in T- and B-lymphocytes and granulocytes in workers exposed to benzene
- Authors
- Sul, DG; Lee, D; Im, H; Oh, E; Kim, J; Lee, E
- Issue Date
- 5-8월-2002
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- comet assay; t,t-MA; creatinine; lymphocytes
- Citation
- TOXICOLOGY LETTERS, v.134, no.1-3, pp.87 - 95
- Indexed
- SCIE
SCOPUS
- Journal Title
- TOXICOLOGY LETTERS
- Volume
- 134
- Number
- 1-3
- Start Page
- 87
- End Page
- 95
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/124380
- DOI
- 10.1016/S0378-4274(02)00167-4
- ISSN
- 0378-4274
- Abstract
- Comet assays were carried out to evaluate DNA damage in T- and B-lymphocytes and granulocytes from 41 workers exposed to benzene in a printing company and 41 unexposed donors. In T-lymphocytes, DNA damage was slightly higher in exposed workers than in controls. The tail moments in the two groups were 1.75 +/- 0.29 and 1.47 +/- 0.41, respectively (P < 0.0006). DNA damage of B-lymphocytes in the two groups showed the most significant difference among the three cell types. The tail moments were 3.86 +/- 0.71 and 1.51 +/- 0.39, respectively (P < 0.0001). In granulocytes, DNA damage was also different, the tail moments being 3.61 +/- 0.75 and 2.60 +/- 0.59, respectively (P < 0.0001). The comparison of DNA damage in both groups shows that B-lymphocytes could be a useful target in biomonitoring of human exposure to low levels of benzene. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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