Anti-inflammatory effects of IL-4 and IL-10 on human polymorphonuclear leukocytes
- Authors
- Lee, SW; Hong, YS; Chun, CM; Moon, JD; Kim, SJ; Jung, IC; Yoon, YH; Lee, BA; Moon, SW; Choi, SH; Moon, CK
- Issue Date
- 2월-2002
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- interleukin-4; interleukin-10; interleukin-8; tumor necrosis factor-alpha; N-formylmethionine leucyl-phenylatanine; neutrophils
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.17, no.1, pp.7 - 14
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 17
- Number
- 1
- Start Page
- 7
- End Page
- 14
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/124387
- DOI
- 10.3346/jkms.2002.17.1.7
- ISSN
- 1011-8934
- Abstract
- Inflammatory responses are strictly regulated by coordination of pro-inflammatory and anti-inflammatory mediators. Interleukin-4 (IL-4) and interleukin-10 (IL-10) have typically the biologic anti-inflammatory effects on monocytes, but uncertain effects on polymorphonuclear leukocytes (PMNs). The PMNs are the first line of cellular response for host defense during acute inflammation. To modify hyper-inflammatory reaction with biologic anti-inflammatory mediators' we have determined the biologic anti-inflammatory activities of IL-4 and IL-10 on human PMNs. Human PMNs were pretreated with IL-4 or IL-10 and then stimulated with formyl methionyl leucyl phenylalanine (fMLP) for times indicated. The level of H2O2, interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) were determined in the each cell free supernatants. fMLP plays the role of a typical pro-inflammatory agent and, at least in determined conditions, clown-regulated TNF release. IL-4 acts as an anti-inflammatory mediator but IL-10 did not show its anti-inflammatory activities on fMLP-stimulated human PMNs. IL-4 and IL-10 have different anti-inflammatory mechanisms. Perhaps, IL-10 needs co-factors to act as an anti-inflammatory mediator.
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