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Anti-inflammatory effects of IL-4 and IL-10 on human polymorphonuclear leukocytes

Authors
Lee, SWHong, YSChun, CMMoon, JDKim, SJJung, ICYoon, YHLee, BAMoon, SWChoi, SHMoon, CK
Issue Date
2월-2002
Publisher
KOREAN ACAD MEDICAL SCIENCES
Keywords
interleukin-4; interleukin-10; interleukin-8; tumor necrosis factor-alpha; N-formylmethionine leucyl-phenylatanine; neutrophils
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.17, no.1, pp.7 - 14
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume
17
Number
1
Start Page
7
End Page
14
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/124387
DOI
10.3346/jkms.2002.17.1.7
ISSN
1011-8934
Abstract
Inflammatory responses are strictly regulated by coordination of pro-inflammatory and anti-inflammatory mediators. Interleukin-4 (IL-4) and interleukin-10 (IL-10) have typically the biologic anti-inflammatory effects on monocytes, but uncertain effects on polymorphonuclear leukocytes (PMNs). The PMNs are the first line of cellular response for host defense during acute inflammation. To modify hyper-inflammatory reaction with biologic anti-inflammatory mediators' we have determined the biologic anti-inflammatory activities of IL-4 and IL-10 on human PMNs. Human PMNs were pretreated with IL-4 or IL-10 and then stimulated with formyl methionyl leucyl phenylalanine (fMLP) for times indicated. The level of H2O2, interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) were determined in the each cell free supernatants. fMLP plays the role of a typical pro-inflammatory agent and, at least in determined conditions, clown-regulated TNF release. IL-4 acts as an anti-inflammatory mediator but IL-10 did not show its anti-inflammatory activities on fMLP-stimulated human PMNs. IL-4 and IL-10 have different anti-inflammatory mechanisms. Perhaps, IL-10 needs co-factors to act as an anti-inflammatory mediator.
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