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Synthesis and characterization of polar functional group substituted mono- and bis-(o-carboranyl)-1,3,5-triazine derivatives
- Authors
- Lee, Chai-Ho; Jin, Guo Fan; Yoon, Ji Ho; Jung, Young Ju; Lee, Jong-Dae; Cho, Sungdong; Nakamura, Hiroyuki; Kang, Sang Ook
- Issue Date
- 1-1월-2008
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Citation
- TETRAHEDRON LETTERS, v.49, no.1, pp.159 - 164
- Indexed
- SCIE
SCOPUS
- Journal Title
- TETRAHEDRON LETTERS
- Volume
- 49
- Number
- 1
- Start Page
- 159
- End Page
- 164
- ISSN
- 0040-4039
- Abstract
- Synthesis, structural characterization, and biological activity studies of o-carborane-substituted 1,3,5-triazines (9-12) containing polar functional groups such as methoxyethyl and t-butoxycarbonylmethyl amine units are described. De-methylation of di(methoxyethyl)amine functionalized triazines 9 and 10 resulted in the production of di(hydroxyethyl)amine derivatives 13 and 14. NNIR (H-1 and C-13) and X-ray crystallographic studies confirmed the structures derived from the sequential o-carborane substitution on the 1,3,5-triazine core. Preliminary in vitro studies revealed that compounds 9, 10, 13, and 14, despite their low cytotoxicity, accumulated at high levels in B-16 melanoma cells. (c) 2007 Elsevier Ltd. All rights reserved.
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