비장적출술로 호전된 불응성 혈전성 혈소판감소성 자반증 1예A Case of Splenectomy in a Patient with Refractory Thrombotic Thrombocytopenic Purpura
- Other Titles
- A Case of Splenectomy in a Patient with Refractory Thrombotic Thrombocytopenic Purpura
- Authors
- 이재원; 김선철; 오세원; 차진주; 김혜원; 부창수; 이지은; 권영주; 표희정
- Issue Date
- 2008
- Publisher
- 대한신장학회
- Keywords
- Thrombotic thrombocytopenic purpura; Splenectomy
- Citation
- Kidney Research and Clinical Practice, v.27, no.2, pp.243 - 247
- Indexed
- KCI
- Journal Title
- Kidney Research and Clinical Practice
- Volume
- 27
- Number
- 2
- Start Page
- 243
- End Page
- 247
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/124689
- ISSN
- 2211-9132
- Abstract
- The introduction of plasma exchange has significantly improved the outcome of thrombotic thrombocytopenic purpura (TTP) and the survival rate was increased from 10 to 80-90%. TTP refractory to plasma exchange therapy, however, is still a therapeutic challenge. We describe here a patient who partially responded to plasma exchange therapy, but remained dependent on plasma infusions. To discontinue plasma therapy, several attempts using agents such as rituximab, vincristine, and cyclosporine A had been tried, but all failed. After splenectomy, serum LDH and blood platelet count were normalized. Plasmapheresis were we able to discontinue after 2 weeks of splenectomy. Steroid and cyclosporine were tapered off after 3 months and 5 months after splenectomy respectively, and the patient has been staying in remission ever since. We suggest that splenectomy is a worthwhile treatment option in patients with refractory TTP.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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