당뇨족 궤양의 치료를 위한 신선 섬유아세포 동종이식
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 심재선 | - |
dc.contributor.author | 한승규 | - |
dc.contributor.author | 김우경 | - |
dc.date.accessioned | 2021-09-09T14:23:19Z | - |
dc.date.available | 2021-09-09T14:23:19Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 2234-6163 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/124894 | - |
dc.description.abstract | Purpose: In order to overcome the limitations of the conventional cryopreserved fibroblast or keratinocyte allograft method used in the treatment of diabetic foot ulcers, we reported a pilot study in 2004 demonstrating promising results of a fresh fibroblast allograft method in eight patients. However, the number of cases was insufficient for full evaluation and the follow-up duration was not long enough to determine the efficacy and safety of the method. This encouraged us to conduct this follow-up study to fully evaluate the use of noncryopreserved fresh human fibroblast allografts in treating diabetic foot ulcers. Methods: Thirty-seven patients with diabetic foot ulcers were treated using fresh fibroblast allografts. Human dermal fibroblasts from healthy teenagers were cultured in DMEM/F-12 medium supplemented with 10% serum. The cultured cells were applied on the wounds immediately following debridement, with fibrin being used as a cell carrier. In eight weeks, percentages of complete healing, mean healing time, and patient satisfactions were assessed, with follow-up time ranging from 6 to 40 months. Results: Our study showed that 83.8% of the treated patients were complete healed. The time required for complete healing was 30.9±10.1 days. Patient satisfaction scores for the experimental treatment were higher than those for the conventional method(mean scores of 8.1±1.1 and 4.8±1.4, respectively). No adverse events related to the study treatment occurred. Conclusion: The use of fresh human fibroblast allografts was found to be a safe and effective treatment for diabetic foot ulcers. | - |
dc.language | Korean | - |
dc.language.iso | ko | - |
dc.publisher | 대한성형외과학회 | - |
dc.title | 당뇨족 궤양의 치료를 위한 신선 섬유아세포 동종이식 | - |
dc.title.alternative | Fresh Fibroblast Allograft as a Treatment for Diabetic Foot Ulcers | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 한승규 | - |
dc.contributor.affiliatedAuthor | 김우경 | - |
dc.identifier.bibliographicCitation | Archives of Plastic Surgery, v.35, no.5, pp.501 - 506 | - |
dc.relation.isPartOf | Archives of Plastic Surgery | - |
dc.citation.title | Archives of Plastic Surgery | - |
dc.citation.volume | 35 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 501 | - |
dc.citation.endPage | 506 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001277505 | - |
dc.description.journalClass | 2 | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Diabetic foot | - |
dc.subject.keywordAuthor | Fibroblast | - |
dc.subject.keywordAuthor | Diabetic foot | - |
dc.subject.keywordAuthor | Fibroblast | - |
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