당뇨족 궤양의 치료를 위한 신선 섬유아세포 동종이식Fresh Fibroblast Allograft as a Treatment for Diabetic Foot Ulcers
- Other Titles
- Fresh Fibroblast Allograft as a Treatment for Diabetic Foot Ulcers
- Authors
- 심재선; 한승규; 김우경
- Issue Date
- 2008
- Publisher
- 대한성형외과학회
- Keywords
- Diabetic foot; Fibroblast; Diabetic foot; Fibroblast
- Citation
- Archives of Plastic Surgery, v.35, no.5, pp.501 - 506
- Indexed
- KCI
- Journal Title
- Archives of Plastic Surgery
- Volume
- 35
- Number
- 5
- Start Page
- 501
- End Page
- 506
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/124894
- ISSN
- 2234-6163
- Abstract
- Purpose: In order to overcome the limitations of the conventional cryopreserved fibroblast or keratinocyte allograft method used in the treatment of diabetic foot ulcers, we reported a pilot study in 2004 demonstrating promising results of a fresh fibroblast allograft method in eight patients. However, the number of cases was insufficient for full evaluation and the follow-up duration was not long enough to determine the efficacy and safety of the method. This encouraged us to conduct this follow-up study to fully evaluate the use of noncryopreserved fresh human fibroblast allografts in treating diabetic foot ulcers.
Methods: Thirty-seven patients with diabetic foot ulcers were treated using fresh fibroblast allografts. Human dermal fibroblasts from healthy teenagers were cultured in DMEM/F-12 medium supplemented with 10% serum. The cultured cells were applied on the wounds immediately following debridement, with fibrin being used as a cell carrier. In eight weeks, percentages of complete healing, mean healing time, and patient satisfactions were assessed, with follow-up time ranging from 6 to 40 months.
Results: Our study showed that 83.8% of the treated patients were complete healed. The time required for complete healing was 30.9±10.1 days. Patient satisfaction scores for the experimental treatment were higher than those for the conventional method(mean scores of 8.1±1.1 and 4.8±1.4, respectively). No adverse events related to the study treatment occurred.
Conclusion: The use of fresh human fibroblast allografts was found to be a safe and effective treatment for diabetic foot ulcers.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.