양극성 장애 환자에서 급성 조증기 및 관해기 사이의 인지기능 변화와 조증 증상과의 상관성Changes of Cognitive Function and the Relationship with Manic Symptoms between Acute Manic and Euthymic States in Patients with Bipolar Disorder
- Other Titles
- Changes of Cognitive Function and the Relationship with Manic Symptoms between Acute Manic and Euthymic States in Patients with Bipolar Disorder
- Authors
- 허지원; 김용구
- Issue Date
- 2008
- Publisher
- 대한신경정신의학회
- Keywords
- 양극성장애·조증·관해·인지기능·주의력·기억력·실행기능.; Bipolar disorder·Manic·Remission·Cognition·Attention·Memory·Neuropsychology.
- Citation
- 신경정신의학, v.47, no.4, pp.325 - 333
- Indexed
- KCI
- Journal Title
- 신경정신의학
- Volume
- 47
- Number
- 4
- Start Page
- 325
- End Page
- 333
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/125376
- ISSN
- 1015-4817
- Abstract
- Objectives:The purpose of this study was to investigate 1) whether the change of manic symptoms in bipolar patients would
be correlated with cognitive functions and 2) whether there would be significant changes in the cognitive function between
acute manic and euthymic states.
Methods:The thirty-five patients who were diagnosed as manic episode by DSM-IV and SCID-IV interview participated in
this study. The memory function, executive function, and sustained attention were measured using Memory Assessment Scale
(MAS), Wisconsin Card Sorting Test (WCST), and Vigilance (VIG) and Cognitrone (COG) in the Vienna Test System respectively.
The psychopathology was measured using Young Mania Rating Scale (YMRS) and Brief Psychiatric Rating Scale
(BPRS) by a trained psychologist. After 6 weeks of drug treatment, the cognitive tests and psychopathology were retested by
the same psychologist.
Results:The normal control group (N=76) and bipolar disorder patients group (N=35) showed different neurocognitive
performance which were performed at baseline. After 6 weeks of medication, the YMRS and BPRS scores in the patient group
decreased significantly. Although the psychiatric symptoms were attenuated, most of the neurocognitive functions including
attention, psychomotor speed, memory (N=34), and frontal/executive function (N=35) were still impaired after treatment.
Furthermore, the correlations between the variation of psychiatric symptoms and the differences in neurocognitive functions were
statistically insignificant.
Conclusion:This study provides an evidence for distinct neuropsychological dysfunctions in acute manic state in bipolar
disorder patients. Besides, the impairments of neuropsychological functioning remain after medication and remission. These
neuropsychological dysfunctions might be one of the trait markers of the disorder, and we suggest that the dysfunctions make
the bipolar disorder patients with medication still experience difficult to adjust daily life. (J Korean Neuropsychiatr Assoc 2008;
47(4):325-333)
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.